Job ID
REQ-10067032
November 26, 2025
Switzerland
Summary
Location: Basel, Switzerland #onsite
We have an exciting opportunity for an Oligonucleotide Chemist in our CHAD department here in Basel.
About the Role
Your responsibilities include, but are not limited to:
- Defining fit-for-purpose synthesis strategies for drug substance manufacturing and Health Authority documentation.
- Developing efficient and scalable oligonucleotide processes for relevant projects within the Novartis portfolio across different scales.
- Being part of the Oligo chemist/engineering team to develop and optimize syntheses used in process R&D.
- Investigating various approaches for oligonucleotide preparation and evaluating their potential by applying cutting-edge automated platforms.
- Ensuring the utilization of state-of-the-art technologies and science.
- Efficient use of lab resources.
- Maintaining oversight on process safety.
- Co-leading the process transfer to pilot plants.
- Serving as consultants for troubleshooting during campaigns.
- Collaborating with internal and external stakeholders or partners.
- Collaborating with diverse experts in the areas of Nucleic Acid Chemistry, Process Chemistry, Process Engineering, and Analytics.
What You'll Bring to the Role
- A completed PhD in Organic Chemistry or Chemical Engineering.
- PostDoc experience focusing on oligonucleotide processes.
- Experience in developing platform synthesis concepts for oligonucleotides.
- Experience in process development using state-of-the-art oligo synthesizers.
- Experience in downstream processing, including TFF and chromatographic processes.
- An excellent track record of original research and extensive experience in utilizing state-of-the-art technologies.
- Fluency in English.
Commitment to Diversity and Inclusion
Novartis is dedicated to fostering an inclusive work environment and building diverse teams that reflect the patients and communities we serve.
Accessibility and Accommodation
Novartis is committed to working with and providing reasonable accommodation to all individuals. If you require assistance due to a medical condition or disability during the recruitment process, please reach out to inclusion.switzerland@novartis.com with the nature of your request and contact information. Remember to include the job requisition number in your message.
Why Novartis
At Novartis, improving the lives of people with diseases and their families requires more than innovative science. It involves a community of passionate and intelligent individuals collaborating, supporting, and inspiring one another. Together, we achieve breakthroughs that significantly change patients' lives. Ready to create a brighter future together? Learn more.
Benefits and Rewards
To discover more about the ways we support your personal and professional growth, please refer to our handbook.
Apply online using the form below. Only applications matching the job profile will be considered.
Division
Development
Business Unit
Development
Location
Switzerland
Site
Basel (City)
Company / Legal Entity
C028 (FCRS = CH028) Novartis Pharma AG
Functional Area
Research & Development
Job Type
Full time
Employment Type
Regular
Shift Work
No
Novartis is committed to maintaining an outstanding and inclusive work environment, with diverse teams that are representative of the patients and communities we serve.
Work locationBASEL, Switzerland