PhD Candidate in Metabolic Discovery and Mechanistic Physiology using Exhalomics in Dairy Cows / PhD Candidate in Metabolic Discovery and Mechanistic Physiology using Exhalomics in Dairy Cows

PhD Position in Metabolic Discovery and Mechanistic Physiology using Exhalomics in Dairy Cows

100%, Zurich, fixed-term

The Animal Nutrition group at ETH Zurich invites applications for a PhD position focusing on the intersection of ruminant nutrition, animal health, and physiological phenotyping using emerging non-invasive exhalomics (exhaled breath metabolomics). This innovative research program integrates animal experiments with advanced analytical techniques and bioinformatics to enhance our understanding of physiological metabolism in dairy cows. The successful candidate will collaborate within a dynamic research team led by Mutian Niu, benefiting from access to a state-of-the-art dairy research facility, a metabolic center, and high-resolution analytical platforms.

Project Background

The PhD candidate will engage in three primary research components centered around exhalomics and its applications to animal physiology and health:

• Nutrient Metabolism in Dairy Cows: Conduct controlled nutritional experiments to assess how dietary factors influence rumen function and metabolic responses.
• Immune Challenges and Early Detection of Health Perturbations: Perform immune-based animal experiments using LPS challenges to analyze how inflammatory states modify metabolic signatures in dairy cows.
• Large-Scale Exhalomics in Dairy Cows: Carry out observational studies comparing exhaled breath profiles of healthy and hospitalized animals.

Across these components, the project will leverage high-resolution mass spectrometry and complementary data streams to explore how exhaled metabolites reflect physiological status.

Job Description

• Conduct in vivo/in vitro experiments in collaboration with an experienced team.
• Perform physiological and metabolic sampling (rumen, breath, blood, fecal, urine, milk).
• Operate, integrate, extract, and interpret data from high-resolution mass spectrometry platforms.
• Organize, manage, and analyze large datasets, including bioinformatics.
• Communicate scientific results in both written and oral forms, including conference presentations.
• Publish findings in peer-reviewed journals.
• Actively participate in group meetings and collaborative research discussions.
• Support other team members in their animal experiments and projects.

Profile

Required Qualifications

• Master’s degree in Animal Science, Biology, Physiology, Veterinary Science, Biochemistry, Bioinformatics, or related fields.
• Ability to perform structured, well-documented experimental work.
• Strong motivation to work with animals.
• Curiosity for science.
• Good communication and teamwork skills.
• Proficient in the English language.

Desired Skills (but not required)

• Experience with nutritional, immunological (LPS), or metabolic models in animals.
• Familiarity with laboratory techniques in biochemistry, metabolomics, or bioinformatics.
• Exposure to mass spectrometry or analytical chemistry tools.
• Statistical/data science/bioinformatics tools.

Workplace

ETH Zurich offers a stimulating research environment and unparalleled opportunities for professional growth. You will have access to state-of-the-art facilities and datasets, collaborations with various research organizations and industry partners, and a competitive salary in accordance with ETH Zurich standards. Additionally, our commitment to fostering a diverse and inclusive environment ensures that everyone's rights and dignity are respected.

We Value Diversity and Sustainability

ETH Zurich encourages an inclusive culture that values equality of opportunity and promotes diversity. We nurture a working and learning environment where all staff and students can thrive. Sustainability is a core value for us, and we are actively working towards a climate-neutral future.

Curious? So Are We.

We look forward to your online application, which should include:

• A cover letter outlining your motivation and fit for the role.
• A detailed CV with a publication list and relevant experience.
• BSc and MSc transcripts.
• A copy of your Master’s thesis (if available).
• Contact details for 2-3 professional references.

Apply online using the form below. Only applications matching the job profile will be considered.

About ETH Zurich

ETH Zurich is a leading university specializing in science and technology, renowned for excellent education, cutting-edge research, and the direct transfer of knowledge into society. With over 30,000 individuals from over 120 countries, our university promotes independent thinking and inspires excellence. Situated in the heart of Europe, we collaborate globally to address the challenges of today and tomorrow.