Job ID
REQ-10074527
Location
Basel, Switzerland
Summary
Full-time, onsite, #LI-Onsite
In the Immunology group of Biomedical Research, we are dedicated to developing the next generation of medicines for inflammatory bowel disease, with the ambition to transform the lives of patients. This is an opportunity for you to bring your scientific talent and curiosity into a highly collaborative and interdisciplinary environment. Your work will transform complex human data into actionable therapy-relevant insights in a competitive and dynamic field.
About the Role
The Translational Inflammatory Bowel Disease (IBD) lab is integrated within the Immunology Research Disease Area, aimed at accelerating target discovery and positioning of therapeutic compounds for IBD (Ulcerative Colitis and Crohn's disease). We are seeking a scientist with a strong background in mechanistic translational research in mucosal immunology to lead our lab research activities. If you are passionate about the molecular basis of IBD and compound mechanisms of action at the interface of preclinical and clinical research, we invite you to join our team.
Key Responsibilities
- Design and execute mechanistic experiments: Link human disease biology to druggable targets within and beyond the immune system and accelerate preclinical compound development, strengthen understanding of drug modes of action, and differentiate novel drugs from standard-of-care treatment.
- Leverage human biosamples: Utilize samples such as blood and intestinal biopsies to generate decision-making data and position candidate molecules for clinical trials (target validation, MOA studies, biomarker strategy).
- Collaborate with early clinical teams: Work closely with Biomarker Development and Translational Medicine to test clinical hypotheses for early clinical strategies, including patient stratification.
- Champion data-driven target discovery: Collaborate with data scientists, in vivo biology labs, and other groups in Novartis Biomedical Research to connect quantitative methods (e.g., ex vivo analyses and transcriptomics) to patient heterogeneity and outcomes.
- Promote a culture of collaboration: Foster talent development and uphold integrity within the team.
Minimum Requirements
- Education: Ideally, a PhD or MD in Mucosal Immunology, Gastroenterology, Barrier Immunology (skin/lung/intestine), or a related field, with a strong track record of peer-reviewed publications.
- Experience: At least 3 years of relevant translational research expertise in an interdisciplinary setting in academia or industry, bridging clinical and preclinical evidence.
- Skills: Hands-on mastery of routine immunological, cell biology, and molecular biology assays (e.g., multi-parametric flow cytometry) and in vitro human models relevant to IBD and mucosal immunity (e.g., primary immune/epithelial cells, slice cultures).
- Proficiency: Proven ability to conduct experiments using in vitro human systems and biosamples (e.g., PBMCs, primary immune/epithelial cells, tissue explants), including sample-tracking best practices and ethics.
- Collaboration: Experienced in collaborating with data scientists, ensuring high-quality experimental design and reproducibility.
- Project Management: Demonstrated track record of completing projects on schedule within narrow timelines.
Additional Requirements
- Prior experience mentoring junior researchers is a plus.
- Experience contributing to drug discovery programs in biotech/pharma or translational academic/clinical settings (e.g., in vitro pharmacology, biomarker studies) is advantageous.
- Data science literacy with the ability to interpret multi-omic outputs and statistical analyses is an asset.
Restrictions on flexible working requirements may apply and can be discussed during the interview stages as necessary.
Accessibility and Accommodation
Novartis is committed to providing reasonable accommodations for individuals with medical conditions or disabilities. If you require accommodation during the recruitment process or need more detailed information about the essential functions of a position, please contact us at inclusion.switzerland@novartis.com with your request and contact information. Please include the job requisition number in your message.
Why Novartis
Helping people with diseases and their families takes more than innovative science; it takes a community of smart, passionate individuals like you. By collaborating, supporting, and inspiring each other, we achieve breakthroughs that change patients' lives. Are you ready to create a brighter future together? Learn more about us.
Benefits and Rewards
Discover all the ways we support your personal and professional growth. Read our handbook (PDF 30 MB).
Division
Biomedical Research
Business Unit
Research
Job Type
Full-time
Employment Type
Regular
Shift Work
No
Application
Apply online using the form below. Only applications matching the job profile will be considered.