Chief Medical Officer / Chief Medical Officeress

About SJP Biotec GmbH

SJP Biotec GmbH is a clinical-stage precision oncology company pioneering a first-in-class Selective Translation Regulatory Inhibitor (STRI) platform designed to address treatment resistance in refractory cancers. Founded in 2024, SJP focuses on RAS-driven, hormone-receptor-positive, and immune-refractory tumors, developing a promising pipeline of small molecules ready to advance into regulatory-grade trials.

Our Scientific Advisory Board comprises world-renowned experts in RAS and breast cancer biology, as well as immuno-oncology. SJP has forged clinical partnerships with leading medical centers worldwide, including UCSF, NCI, MD Anderson, Baylor College of Medicine, MSKCC, and McGill, among others.

The Opportunity

This is a dynamic opportunity to join a scientifically exceptional and capital-efficient biotech company at a pivotal moment in its development. The Chief Medical Officer (CMO) / Senior Vice President (SVP) of Clinical Development will serve as the company’s most senior clinical leader, responsible for designing and executing a multi-indication clinical development strategy in one of the most exciting areas of oncology drug development: RAS/eIF4A/translation-pathway inhibition.

Key Responsibilities

• Translate and deliver key directives from the board and senior management, acting as the clinical face of the company.
• Lead and manage all clinical development activities across the SJP portfolio.
• Design Phase 2 and 3 clinical protocols and oversee CTA/IND submissions to BfArM, FDA, and EMA.
• Develop and implement biomarker-driven patient selection strategies.
• Build and maintain relationships with leading academic and clinical sites across Germany, the EU, and the US.
• Oversee Investigator Initiated Trials and partnerships, providing scientific leadership as necessary.
• Lead regulatory strategy, developing approaches for Fast Track Designation, Breakthrough Therapy Designation, and accelerated approval pathways when applicable.
• Support pharmaceutical partnering activities by preparing clinical data packages and responding to due diligence for potential licensing and out-licensing transactions.
• Build out the clinical development and operations function, including recruitment of Clinical Research Associates (CRAs), medical monitors, and data management staff.
• Present clinical data at major oncology congresses and to key opinion leaders.
• Engage with potential investors and financial institutions to secure capital when necessary.

Candidate Profile

Essential Qualifications

• MD with specialization in medical oncology and hematology.
• 10+ years of experience in oncology clinical development within pharma, biotech, or CRO environments, with hands-on clinical trial leadership.
• Demonstrated track record of successful IND/CTA submissions.
• Leadership experience in interactions with FDA and/or EMA.
• Expertise in biomarker-driven trial design and companion diagnostic development.
• In-depth knowledge of breast cancer, NSCLC, and KRAS-mutant tumor biology.
• Strong understanding of the competitive treatment landscape in clinical oncology.
• Proven ability to manage investigator-initiated trials and develop academic site partnerships.
• Strong scientific publication and/or congress presentation record in clinical oncology.
• Excellent presentation skills with an emphasis on teamwork and leading a team of experts.

Highly Desired (But Not Required)

• Experience with RAS/KRAS biology, MAPK pathway inhibitors, or translation-pathway therapeutics.
• PhD in an associated area of cancer biology.
• Experience with basket trial design and multi-cohort oncology studies.
• Background in immuno-oncology combinations, particularly in checkpoint inhibitor resistance settings.
• Prior experience in pharma partnering or licensing due diligence from the biotech perspective.
• Working knowledge of German regulatory frameworks alongside international GCP/ICH guidelines.
• Established professional network at leading cancer centers.

How to Apply

Apply online using the form below. Only applications matching the job profile will be considered.