Chief Medical Officer / Chief Medical Officer

Company Overview

SJP Biotec GmbH is a clinical-stage precision oncology company that is pioneering a first-in-class Selective Translation Regulatory Inhibitor (STRI) platform designed to overcome treatment resistance in refractory cancers. Founded in 2024, SJP focuses on tackling RAS-driven, hormone-receptor-positive, and immune-refractory tumors through a novel pipeline of small molecules developed in-house, poised for regulatory-grade trials.

Backed by a distinguished Scientific Advisory Board comprising world-leading experts in RAS and breast cancer biology as well as immuno-oncology, SJP has established clinical partnerships with prominent medical centers across the globe, including UCSF, NCI, MD Anderson, Baylor College of Medicine, MSKCC, and McGill, among others.

The Opportunity

This is a stimulating and unique opportunity to join a scientifically exceptional, capital-efficient biotech company engaged in groundbreaking work at a pivotal moment. The Chief Medical Officer (CMO)/Senior Vice President (SVP) of Clinical Development will assume the role of the company's most senior clinical leader, responsible for designing and executing a multi-indication clinical development strategy focused on one of the most exciting areas in oncology drug development: RAS/eIF4A/translation-pathway inhibition.

Key Responsibilities

• Translate and implement key directives from the board and senior management, acting as the clinical face of the company.
• Lead and manage all clinical development activities across the SJP portfolio.
• Design Phase 2 and 3 clinical protocols while overseeing CTA/IND submissions to BfArM, FDA, and EMA.
• Develop and implement biomarker-driven patient selection strategies.
• Build and nurture relationships with leading academic and clinical sites across Germany, the EU, and the US.
• Oversee Investigator Initiated Trials and partnerships, providing scientific leadership as needed.
• Lead regulatory strategy, developing approaches for Fast Track Designation, Breakthrough Therapy Designation, and accelerated approval pathways as applicable.
• Support pharmaceutical partnering activities, preparing clinical data packages and addressing due diligence for potential licensing and out-licensing transactions.
• Build out the clinical development and operations function, including the recruitment of CRAs, medical monitors, and data management staff.
• Present clinical data at major oncology congresses and to key opinion leaders.
• Engage with potential investors and financial institutions to raise capital when needed.

Candidate Profile

Essential Qualifications

• MD with specialization in medical oncology and hematology.
• 10+ years of experience in oncology clinical development within pharma, biotech, or CRO environments, with hands-on clinical trial leadership.
• Demonstrated success in IND/CTA submissions.
• Experience leading interactions with FDA and/or EMA.
• Expertise in biomarker-driven trial design and companion diagnostic development.
• In-depth knowledge of breast cancer, NSCLC, and KRAS-mutant tumor biology.
• Strong understanding of the competitive treatment landscape in clinical oncology.
• Proven ability to manage investigator-initiated trials and academic site partnerships.
• Robust scientific publication and/or congress presentation record in clinical oncology.
• Excellent presentation skills, with an emphasis on teamwork and leading a team of experts in their fields.

Highly Desired (But Not Required)

• Experience with RAS/KRAS biology, MAPK pathway inhibitors, or translation-pathway therapeutics.
• PhD in a relevant area of cancer biology.
• Experience with basket trial design and multi-cohort oncology studies.
• Background in immuno-oncology combinations, particularly related to checkpoint inhibitor resistance.
• Prior involvement in pharma partnering or licensing due diligence from a biotech perspective.
• Working knowledge of German regulatory frameworks alongside international GCP/ICH guidelines.
• Established professional network at leading cancer centers.

How to Apply

To join our team and make a difference in oncology drug development, apply online using the form below. Please note that only applications matching the job profile will be considered.