Job ID
REQ-10066548
Date: November 18, 2025
Location: Basel, Switzerland #onsite
Summary
We are seeking a highly motivated and experienced PhD-level scientist to lead our mid/large xRNA synthesis team in Basel. This role necessitates extensive collaboration within a multidisciplinary environment, seamlessly bridging research and development to discover and advance innovative siRNA therapies aimed at addressing significant unmet medical needs.
About the Role
Key Responsibilities
- Oversee a state-of-the-art oligonucleotide synthesis facility, managing both capital and consumable budgets efficiently.
- Lead and guide a team of scientists specializing in oligonucleotide synthesis and purification of oligonucleotides at millimole scale to deliver on our expanding siRNA portfolio.
- Ensure the delivery of high-quality siRNA products for both in vitro screening and in vivo evaluation within drug candidate pipelines.
- Collaborate with existing discovery xRNA oligonucleotide synthesis teams in Basel and Cambridge.
- Provide technical leadership to the scale-up team in the synthesis of oligonucleotides, optimizing methodologies and processes to enhance efficiencies.
- Work collaboratively with synthetic chemists and project teams to scale up new siRNA chemistries that address critical scientific challenges, facilitating their seamless transition into development.
- Document and effectively communicate results and scientific insights to internal and external stakeholders through patent applications and scientific publications.
- Mentor and support team members by sharing technical expertise and hands-on experience within the work environment.
- Exhibit excellent problem-solving skills and a solution-oriented mindset.
Qualifications and Requirements
- A PhD in synthetic chemistry with a focus on oligonucleotides and 2-3 years of experience in an industry setting.
- Proven practical experience in oligonucleotide solid phase synthesis and downstream processing, with expertise in mid/large scale oligo synthesis and process development.
- Demonstrated leadership abilities and experience in developing scientific teams.
- Ability to promote and implement innovative ideas within a global team context.
- Strong independent problem-solving skills.
- Proven collaborative attitude.
- Proficiency in managing multiple priorities effectively while maintaining focus.
- Excellent verbal and written communication abilities.
Commitment to Diversity and Inclusion
At Novartis, we are committed to building an outstanding, inclusive work environment and diverse teams that represent the patients and communities we serve.
Accessibility and Accommodation
Novartis is dedicated to working with and providing reasonable accommodation to all individuals. If, due to a medical condition or disability, you require reasonable accommodation during the recruitment process, or if you need more detailed information about the essential functions of a position, please send an email to inclusion.switzerland@novartis.com. Please include the job requisition number in your message.
Why Novartis
Helping people with diseases and their families takes more than innovative science; it requires a community of intelligent and passionate individuals like you. We work collaboratively, support one another, and inspire each other to achieve breakthroughs that change patients' lives. Are you ready to create a brighter future together?
Learn more about our culture.
Benefits and Rewards
Explore our handbook to discover all the ways we can help you thrive both personally and professionally: View Benefits and Rewards.
Application Process
To apply for this position, please apply online using the form below. Only applications matching the job profile will be considered.
Company Details
Division: Biomedical Research
Business Unit: Research
Location: Switzerland
Site: Basel (City)
Company / Legal Entity: C028 (FCRS = CH028) Novartis Pharma AG
Functional Area: Research & Development
Job Type: Full time
Employment Type: Regular
Shift Work: No