Postdoctoral Researcher / Postdoctoral Researcheress in Development of In Vitro Skin Model Including Sensory Perception

Postdoc Position in Development of In Vitro Skin Model Including Sensory Perception

100%, Basel, fixed-term

We are seeking a highly motivated and enthusiastic Postdoc for a collaboration project between the Bio Engineering Laboratory (Department of Biosystems Science and Engineering of ETH Zurich in Basel) and Novartis AG, Basel, Switzerland. This is a unique opportunity to collaborate across scientific and organizational boundaries, focusing on developing advanced skin models to study barrier function and itching, which may lead to therapeutic breakthroughs for patients.

Project Background

This project aims to leverage cutting-edge cellular models, bioengineering, and microfluidic approaches to develop skin models that incorporate sensory perception. This will enhance our understanding of immunological skin diseases and have practical applications in drug discovery. While current ex vivo skin models are widely used in pharmaceutical and cosmetic research, they are limited in their ability to assess itch-inducing and barrier-compromising conditions in real time. Emerging models using primary keratinocytes and induced pluripotent stem cells (iPSC) offer improved replication of physiological and disease conditions, yet they require adaptation for pharmaceutical research and target identification.

Job Description

• In this collaborative project, you will devise an in vitro 3D human skin model to investigate barrier function under homeostatic conditions and in response to inflammatory stimuli.
• By combining state-of-the-art engineering and microfluidic approaches with innovative cellular models, you will develop skin models that include sensory perception, facilitating applications in fundamental science and drug testing.
• You will play a dual role in setting up and culturing the 3D skin models, as well as optimizing sensor technology (e.g., TEER and TEWL) to enable robust assessments of skin barrier functionality.
• Additionally, you will study itch perception through the integration of iPSC-derived sensory neurons.

Profile

• We are looking for a candidate with a strong background in biology and engineering (e.g., bioengineering, biotechnology, or related fields), possessing solid knowledge of molecular biology and cell culturing, preferably in microphysiological systems.
• Relevant experience includes primary cell culturing, work with advanced in vitro models, epithelial/endothelial barrier characterization, and iPSC differentiation. Skills in optical microscopy, sensor development, and integration, as well as electrophysiology, are advantageous.
• Academic excellence, a professional attitude, and a proactive nature are expected.
• Strong communication skills, fluency in English, and a collaborative mindset are vital for thriving in this international setting.

Workplace

Your position will be fully funded for an initial duration of 2 years, with the possibility of an extension up to 4 years. The starting date is flexible but must be before June 2026.

What We Offer

• Your role will have a significant impact. Join ETH Zurich, where we not only support your professional development but also contribute positively to society.
• You can expect numerous benefits, such as public transport season tickets, car sharing, a wide range of sports offered by the ASVZ, childcare services, and attractive pension benefits.

Diversity and Sustainability

At ETH Zurich, we are committed to promoting an inclusive culture that values diversity and equality of opportunity. We nurture a working and learning environment where the rights and dignity of all staff and students are respected. Visit our Equal Opportunities and Diversity website to learn more about how we provide a fair and supportive environment for growth. Sustainability is a core value for us as we actively work towards a climate-neutral future.

Curious? So Are We!

We invite you to apply online using the form below. Please note that only applications matching the job profile will be considered.

About ETH Zurich

ETH Zurich is one of the world's leading universities specializing in science and technology. We are renowned for our excellent education, groundbreaking research, and the direct transfer of new knowledge into society. With over 30,000 individuals from more than 120 countries, our institution fosters independent thinking and inspires excellence. Located in the heart of Europe, we create connections worldwide to develop solutions for today's global challenges.