Job opportunity

PhD Student in Time-Resolved Structural Biology of Membrane Proteins

Paul Scherrer Institut (PSI) Villigen PSI December 1, 2025

Your Tasks

  • Apply time-resolved cryo-EM and complementary biophysical techniques to capture dynamic structural changes during protein activation with high spatial and temporal resolution.
  • Prepare samples of protein complexes for structural and biophysical studies.
  • Perform cryo-EM data collection, image processing, and 3D reconstruction.
  • Integrate cryo-EM results with additional biophysical data to obtain comprehensive mechanistic insights.
  • Present research findings at national and international scientific conferences.
  • Publish results in peer-reviewed scientific journals.

Your Profile

  • Master's degree in biochemistry, structural biology, or a related discipline, completed before February 2026.
  • Experience in one or more of the following: membrane protein biochemistry/biophysics, cryo-EM, X-ray crystallography, or spectroscopy.
  • Strong motivation to work on ambitious, interdisciplinary projects at the frontier of structural biology.

We Offer

Our institution is built on interdisciplinary, innovative, and dynamic collaboration. You will benefit from systematic on-the-job training, as well as personal development opportunities and a strong vocational training culture. If you seek to harmonize work with family life or other personal interests, we offer modern employment conditions and excellent on-site infrastructure.

The successful candidate will be enrolled in the Life Science Zürich Graduate School at the University of Zürich, gaining access to a tailored PhD training program and teaching responsibilities while having the opportunity to co-supervise students.

For further information, please contact Dr. Polina Isaikina at polina.isaikina@psi.ch.

Apply online using the form below. Only applications matching the job profile will be considered.

Paul Scherrer Institute, Human Resources Management, Pascale Bärtschi, 5232 Villigen PSI, Switzerland

Work locationVilligen PSI, Switzerland

Application Form

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