Senior Scientist / Senior Scientistess - Small Scale Oligonucleotide Synthesis

Job ID: REQ-10071301

Date: Feb 11, 2026

Location: Basel, Switzerland

Employment Type: Full-time, onsite, #LI-Onsite

Summary

At Novartis, we are reimagining medicine to enhance and prolong the lives of individuals. Our commitment to innovative science and technology enables us to tackle some of society's most pressing healthcare challenges. We work tirelessly to discover and develop breakthrough treatments, aiming to broaden access for patients in need. The key to advancing our science lies in empowering curious, courageous, and collaborative individuals to ask new questions, make bold decisions, and take informed risks.

Located in Basel, Switzerland, our Biomedical Research division is at the heart of Novartis’ mission—designing and developing new molecules to treat patients. We are currently seeking a highly motivated researcher with a strong scientific background in chemistry or related life sciences. If you possess a curious mindset and cultural agility, we invite you to join us in inventing innovative medicines and pushing the boundaries of drug discovery.

About the Role

The Biomedical Research RNAi Initiative is looking for a dedicated, creative scientist to become part of our RNA synthesis team. In this role, you will collaborate within a multidisciplinary environment that bridges research and development to discover and develop novel siRNA therapies addressing high unmet medical needs.

Your Responsibilities

• Plan and execute small scale oligonucleotide syntheses using array-based, automated synthetic technologies.
• Conduct experiments in state-of-the-art laboratory facilities and provide novel siRNAs to further therapeutic siRNA projects.
• Collaborate with the project team to integrate experimental data, develop scientific hypotheses, and prioritize new oligonucleotide chemistries to address key project challenges.
• Support and mentor team members by sharing your expertise and insights.
• Present and communicate scientific results during internal meetings and research forums.
• Maintain high standards of laboratory safety and infrastructure.

What You Will Bring to the Role

• Master's degree with a minimum of 3 years of industry experience in a Pharmaceutical Lab, focusing on synthetic organic chemistry. PhD candidates nearing defense may be considered.
• Practical knowledge in small scale oligonucleotide synthesis is essential.
• Familiarity with conjugation to linkers, modifiers, and payloads is an advantage.
• A passion for laboratory experimentation in automated oligonucleotide chemistry.
• Exceptional analytical skills to critically interpret results and formulate new experimental hypotheses.
• Interest in emerging technologies and scientific trends, especially in new drug modalities and their application in drug discovery and development.
• A curious, creative, collaborative mindset, with a commitment to personal and professional growth.
• Strong organizational skills, attention to detail, and a flexible approach to maintaining high quality standards.
• Aptitude for working in a fast-paced, team-oriented environment, while actively contributing to siRNA discovery and development.
• Excellent oral and written communication skills.

Application Process

To apply for this exciting opportunity, please apply online using the form below. Please note that only applications matching the job profile will be considered.

Accessibility and Accommodation

Novartis is committed to providing reasonable accommodations to individuals in need. If you require assistance due to a medical condition or disability during the recruitment process, please reach out to inclusion.switzerland@novartis.com with your request and contact information, including the job requisition number.

Why Novartis

Supporting individuals with diseases and their families demands not just innovative science but also a community of dedicated and passionate professionals. By collaborating, inspiring, and supporting each other, we aim to achieve breakthroughs that transform lives. Are you ready to join us in creating a brighter future?

Learn more about our culture and values here.

Benefits and Rewards

Discover the various ways we support your personal and professional growth by exploring our comprehensive handbook (PDF 30 MB).

Additional Information

Division: Biomedical Research

Business Unit: Research

Location: Switzerland, Basel (City)

Company / Legal Entity: C028 (FCRS = CH028) Novartis Pharma AG

Functional Area: Research & Development

Job Type: Full-time

Employment Type: Regular

Shift Work: No