Senior Scientist / Senior Scientistess - High-Throughput Assay Development for Antibody Discovery
Novartis Pharma AG - May 1, 2025
Job ID
REQ-10048403
Apr 14, 2025
Switzerland
Summary
Location: Basel, Switzerland
Full time, onsite, #LI-Onsite
We are seeking a highly motivated and curious Senior Scientist to join our Biologics Discovery team at the Biomedical Research facility in Basel, Switzerland. You will participate in the generation of high-quality therapeutic antibodies by setting up and conducting high-throughput functional assays for diverse disease applications.
About the Role
Your responsibilities include, but are not limited to:
Develop and operate high-throughput functional cell-based assays (e.g., reporter gene assays, killing assays) for the selection and characterization of antibody drug candidates.
Collaborate closely with the automation team to transfer established assays onto a suitable automation platform for increased throughput and reliability.
Apply multiple cutting-edge selection techniques to synthetic and immune antibody libraries, such as phage display, yeast display, mammalian display, FACS sorting, and plate-based screening. Characterize identified leads through various affinity and activity assays, including ELISA, FACS, Octet, and functional & biochemical assays.
Engineer and improve binders using affinity maturation or humanization techniques.
Analyze experimental data and present scientific interpretations in project team meetings. Contribute to the evaluation or development of new methods and technologies.
Work cooperatively within a team of 3 scientists, reporting to a lab head.
What You Will Bring to the Role
Master's Degree in Molecular & Cell Biology or a related field, with a background in antibody discovery, immunology, or oncology.
At least 5 years of relevant experience in a Biotech or Pharma company.
Proficiency in mammalian cell culture and molecular biology.
Experience in developing and executing high-throughput functional and biochemical assays.
Experience in multiple antibody screening assays including ELISA, FACS, and functional cell-based assays.
Hands-on experience with data analytics platforms or software such as Spotfire.
Hands-on experience with data management systems such as Genedata Biologics is considered a plus.
Hands-on experience in antibody discovery using Phage and/or Yeast Display is considered a plus.
Hands-on experience with liquid handling systems (e.g., Beckman, Hamilton, Tecan) is considered a plus.
Ability to critically interpret results, develop and implement innovative methodologies and processes by taking calculated risks and making smart decisions.
A collaborative mindset, with enthusiasm to develop yourself and others.
A commitment to delivering high-quality data.
Aptitude to work in a fast-paced, team-oriented matrix environment.
Fluency in English is essential (oral/written); advanced knowledge of German and/or French is advantageous.
Restrictions on working flexibility may apply to this position and can be discussed at interview as required.
Accessibility and Accommodation
Novartis is committed to providing reasonable accommodations to all individuals. If, due to a medical condition or disability, you need an accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to Show e-mailm"> and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Why Novartis
Helping people with disease and their families takes more than innovative science; it takes a community of smart, passionate people like you. Collaborating, supporting, and inspiring each other to achieve breakthroughs that change patients' lives. Ready to create a brighter future together? Learn more about us.
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Benefits and Rewards
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How to Apply
Apply online using the form below. Please note that only applications matching the job profile will be considered.
Division
Biomedical Research
Business Unit
Pharma Research
Location
Switzerland
Site
Basel (City)
Company / Legal Entity
C028 (FCRS = CH028) Novartis Pharma AG
Functional Area
Research & Development
Job Type
Full time
Employment Type
Regular
Shift Work
No
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.