Job ID: REQ-10067032
Date: Dec 11, 2025
Location: Basel, Switzerland #onsite
Summary
We have an exciting opportunity for an Oligonucleotide Chemist in our CHAD department here in Basel.
About the Role
Your responsibilities include, but are not limited to:
- Defining fit-for-purpose synthesis strategies for drug substance manufacturing and Health Authority documentation.
- Developing efficient and scalable oligonucleotide processes on relevant projects within the Novartis portfolio across different scales.
- Being part of the Oligo chemist/engineering team to develop and optimize syntheses used in process R&D.
- Investigating various approaches for oligonucleotide preparation and evaluating their potential by applying cutting-edge automated platforms.
- Ensuring the utilization of state-of-the-art technologies and science.
- Efficient use of lab resources.
- Maintaining oversight on process safety.
- Co-leading the process transfer to pilot plants.
- Serving as consultants for troubleshooting during campaigns.
- Collaborating with internal and external stakeholders or partners.
- Working with diverse experts in the areas of Nucleic Acid Chemistry, Process Chemistry, Process Engineering, and Analytics.
What You'll Bring to the Role
- A completed PhD in Organic Chemistry or Chemical Engineering.
- PostDoc experience with a focus on oligonucleotide processes.
- Experience in developing platform synthesis concepts for oligonucleotides.
- Experience in process development using state-of-the-art oligo synthesizers.
- Experience in downstream processing, including TFF and chromatographic processes.
- An excellent track record of original research and extensive experience in using state-of-the-art technologies.
- Fluency in English.
Commitment to Diversity and Inclusion
Novartis is dedicated to fostering an outstanding, inclusive work environment and building diverse teams that represent the patients and communities we serve.
Why Novartis
Helping individuals with diseases and their families requires more than innovative science—it takes a community of smart, passionate people like you. Collaborating, supporting, and inspiring each other to achieve breakthroughs that change patients' lives. Ready to create a brighter future together? Learn more about our culture.
Benefits and Rewards
Explore all the ways we’ll help you thrive personally and professionally in our handbook: Learn more about our benefits.
Application Process
Apply online using the form below. Please note that only applications matching the job profile will be considered.
Division
Development
Business Unit
Development
Location
Switzerland
Site
Basel (City)
Company / Legal Entity
C028 (FCRS = CH028) Novartis Pharma AG
Functional Area
Research & Development
Job Type
Full time
Employment Type
Regular
Shift Work
No
Novartis is committed to building an outstanding, inclusive work environment and diverse teams that represent the patients and communities we serve.