Scientist in AAV Synthetic Biology & Gene Therapy / Scientistess in AAV Synthetic Biology & Gene Therapy

ETH Zurich - June 20, 2025

Scientist in AAV Synthetic Biology & Gene Therapy

Location

100%, Basel, fixed-term

The Biotechnology and Bioengineering group at the Department of Biosystems Science and Engineering (D-BSSE) of ETH Zurich in Basel is seeking scientists who are eager to make a difference. If you thrive on innovation and want to be part of something new and exciting, we would love to hear from you! Our team is looking for talented individuals to join us in launching a new venture focused on cutting-edge research in scalable recombinant Adeno-associated virus (rAAV) manufacturing and closed-loop gene therapies for inborn metabolic disorders.

The D-BSSE is a unique institution where various fields of study converge to foster collaboration. As the first of its kind at the Swiss Federal Institute of Technology, ETH Zurich, our mission is to promote advancements in Systems Biology, Biotechnology, and Synthetic Biology. Here, teams engaged in theoretical biology, experimental biology, and engineering work together, sharing their passion and knowledge to create a positive impact. Our location in beautiful Basel, Switzerland, right in the heart of the Biovalley—a tri-national region housing 40% of the global life science industry—provides an ideal environment for high-leverage translational research.

Project Background

Our group utilizes state-of-the-art principles of Synthetic Biology to engineer human cells and develop advanced gene and cell therapies targeting cancer, as well as metabolic, neurodegenerative, autoimmune, and infectious diseases. For more information, please consult our webpage and published work.

Job Description

We are working on an exciting project aimed at transforming synthetic biology tools into innovative AAV-based therapies. Our objective is to enhance their safety, efficacy, and manufacturability. We are dedicated to overcoming challenges in the gene therapy field, including the production of large quantities of AAV vectors and the development of gene therapies that can adapt dynamically to disease manifestations, maintaining optimal therapeutic protein levels. You will be instrumental in the development, validation, and integration of these technologies, contributing to the roadmap towards clinical translation.

Profile

We are seeking exceptional scientists who are passionate about commercializing startup technologies. You should be a creative and highly motivated individual thriving in a dynamic scientific environment. Additionally, you possess:

  • A PhD in synthetic biology, bioengineering, biotechnology, or a related field
  • A proven track and publication record in academia or industry
  • Experience in mammalian cell engineering, AAV vector design, production, and purification, synthetic gene circuits, inducible expression systems, high-throughput screening, and advanced molecular cloning, along with in vivo preclinical models
  • A strong entrepreneurial mindset
  • A collaborative, motivated, and excellence-driven attitude

Workplace

ETH Zurich is committed to providing a family-friendly environment with excellent working conditions. You can anticipate an exciting workplace featuring cultural diversity and attractive benefits.

We Value Diversity

In alignment with our values, ETH Zurich promotes an inclusive culture that encourages equal opportunity. We celebrate diversity and nurture an environment where the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to learn how we ensure a fair and open environment that allows everyone to grow and thrive.

Curious? So Are We.

We look forward to receiving your online application using the form below. Only applications matching the job profile will be considered. Please include:

  • CV
  • Publication list
  • A motivation letter detailing your scientific background and relevant experience related to the project, along with your enthusiasm for translational synthetic biology, AAVs, and gene therapy.
  • Two letters of recommendation

About ETH Zurich

ETH Zurich is among the world's leading universities specializing in science and technology. Renowned for its excellent education, cutting-edge research, and direct knowledge transfer to society, ETH Zurich is a place where over 30,000 individuals from more than 120 countries find inspiration and promotion of independent thinking. Located in the heart of Europe, we forge connections worldwide, working collaboratively to develop solutions for today's and tomorrow's global challenges.

Location : Zürich
Country : Switzerland

Application Form

Please enter your information in the following form and attach your resume (CV)

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