Scientist in AAV Synthetic Biology & Gene Therapy / Scientistess in AAV Synthetic Biology & Gene Therapy

ETH Zurich - June 16, 2025

Scientist in AAV Synthetic Biology & Gene Therapy

100%, Basel, Fixed-Term

The Biotechnology and Bioengineering group at the Department of Biosystems Science and Engineering (D-BSSE) of ETH Zurich in Basel is actively seeking dedicated scientists eager to make a significant impact. If you thrive on innovation and wish to be part of an exciting new venture, we would love to hear from you! We are in need of talented individuals to join us in launching pioneering research in scalable recombinant Adeno-associated virus (rAAV) manufacturing and closed-loop gene therapies for inborn metabolic disorders.

The D-BSSE is a unique institution where diverse fields converge in perfect harmony. As the first of its kind at the Swiss Federal Institute of Technology, ETH Zurich, our mission is to foster advancement in Systems Biology, Biotechnology, and Synthetic Biology. Here, passionate groups working in theoretical biology, experimental biology, and engineering collaborate to make a meaningful contribution to society. The D-BSSE is situated in the vibrant city of Basel, Switzerland, nestled in Biovalley—a tri-national region that encompasses 40% of the global life science industry, including several pharmaceutical giants, thus providing an exceptional environment for transformative translational research.

Project Background

Our group employs cutting-edge Synthetic Biology principles to engineer human cells and develop innovative gene and cell therapies aimed at addressing cancer as well as metabolic, neurodegenerative, autoimmune, and infectious diseases. For more information, please consult our webpage and published works.

Job Description

We are embarking on an exciting project with the vision of transforming synthetic biology tools into groundbreaking AAV-based therapies. Our aim is to enhance safety, efficacy, and scalability in AAV production. We are tackling several challenges within the gene therapy landscape, such as optimizing large-scale AAV vector production and devising adaptable gene therapies that can respond dynamically to disease progression while maintaining optimal therapeutic protein levels. You will play a crucial role in developing, validating, and integrating these technologies, contributing to the roadmap towards clinical translation.

Profile

We are searching for exceptional scientists who are passionate about commercializing innovative technologies. You are a creative and highly motivated individual who thrives in a dynamic scientific environment. You are enthusiastic about the opportunity to develop and implement cutting-edge technologies. Additionally, you possess:

  • A PhD in synthetic biology, bioengineering, biotechnology, or a related field
  • A proven track record and publication history in academia or industry
  • Experience with mammalian cell engineering, AAV vector design, production, and purification, synthetic gene circuits, inducible expression systems, high-throughput screening, advanced molecular cloning, and in vivo preclinical models
  • A strong entrepreneurial mindset
  • A collaborative, motivated, and excellence-driven attitude

Workplace

ETH Zurich is recognized as a family-friendly employer, offering excellent working conditions. You can anticipate an inspiring work atmosphere, cultural diversity, and attractive benefits.

We Value Diversity

In keeping with our principles, ETH Zurich champions an inclusive culture. We promote equal opportunities, value diversity, and nurture a work and learning environment that respects the rights and dignity of all staff and students. Visit our Equal Opportunities and Diversity website to learn how we maintain a fair and open environment that fosters growth and success for everyone.

Curious? So Are We.

We look forward to receiving your online application including:

  • CV
  • Publication list
  • A motivation letter that outlines your scientific background and experience relevant to the project, as well as your enthusiasm for translational synthetic biology, AAVs, and gene therapy.
  • Two letters of recommendation

Apply online using the form below. Only applications matching the job profile will be considered.

About ETH Zurich

ETH Zurich is one of the world's leading universities specializing in science and technology. Renowned for our excellent education, innovative fundamental research, and the direct application of new knowledge to society, we attract over 30,000 individuals from more than 120 countries. Our institution promotes independent thinking in an environment that inspires excellence. Located in the heart of Europe yet connected globally, together we strive to develop solutions for the pressing challenges of today and tomorrow.

Location : Zürich
Country : Switzerland

Application Form

Please enter your information in the following form and attach your resume (CV)

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