Research Scientist II / Research Scientistess II - Toxicology

Job Overview

#LI-Onsite

Location: Basel, Switzerland

Internal Title: Research Scientist II or Senior Scientist I

We are looking for a highly motivated Associate Scientist to join a multidisciplinary team dedicated to genome safety assessment for advanced therapies. This role focuses on conducting studies necessary for the genotoxicity assessment of gene and cell therapies, including AAV-based approaches and CAR-T platforms. You will have the opportunity to contribute to groundbreaking research addressing integration risk and tumorigenicity in a highly collaborative environment that interfaces with regulatory, nonclinical, and translational teams.

About the Role

This position will primarily support the genome safety assessment of the gene and cell therapy portfolio. Additionally, there will be opportunities for cross-functional contributions to mechanistic safety assessments of other therapeutic modalities, including LMW compounds, xRNA, and biologics. We are seeking individuals who are energized by scientific challenges and a diverse range of activities.

Key Responsibilities

• Conduct in vitro studies to support the genotoxicity assessment of gene therapies (AAVs, lentiviruses, etc.) for regulatory use.
• Support mechanistic evaluation of genome integrity following various gene therapy modalities.
• Generate, analyze, and interpret experimental data to support nonclinical safety assessments.
• Contribute to integration site analysis (ISA) strategies and interpretation.
• Design and execute cell-based assays to investigate DNA damage and mechanisms related to viral integration.
• Develop and implement state-of-the-art technologies and systems for regulatory and investigative genetic toxicity testing across all therapeutic areas and modalities.
• Collaborate with internal experts and external partners to align on study design and data interpretation.
• Document and communicate results through reports, presentations, and regulatory-relevant summaries.

Essential Requirements

• Master’s degree in cellular biology, molecular biology, toxicology, or a related field (No PhD required).
• Experience with mammalian cell culture (both primary cells and established cell lines).
• Proficiency in molecular biology techniques: DNA/RNA extraction, PCR methods, and library preparation for sequencing.
• Basic programming skills for data analysis (R, Python, etc.).
• Strong data interpretation skills and keen attention to detail.
• Able to work independently and collaboratively in a cross-functional environment.
• Effective communication skills, including presentation, manuscript preparation, and collaboration.
• A proactive, flexible mindset with enthusiasm for tackling non-routine scientific challenges.
• Commitment to complying with Good Laboratory Science standards, Safety, Health, and Environment standards.

Desirable Qualifications

• Experience with gene therapy systems (e.g., AAV, lentiviral vectors, CRISPR/Cas9).
• Knowledge of CRISPR/Cas9 editing techniques.
• Experience with DNA damage/repair readouts (e.g., γH2AX, western blot, immunofluorescence, flow cytometry).
• Familiarity with karyotyping, molecular karyotyping, and advanced cytogenetics (FISH, SKY).
• Understanding of genome safety concepts (integration, clonal expansion, tumorigenicity).
• Exposure to primary human cells (e.g., hepatocytes) and/or advanced in vitro models.
• Knowledge of the regulatory context for nonclinical safety.

This is a dual posting. The final level and title of the role will be determined by the hiring team based on the skills, experience, and capabilities needed to perform the role successfully.

Benefits & Rewards

At Novartis, we are committed to reimagining medicine together and rewarding the people who make it happen.

Expected Annual Base Salary Range for the role: 65,870.00 - 122,330.00 CHF Annually

The base salary offered is determined based on relevant skills, competencies, and experience in accordance with the Novartis pay-setting policy and will be reviewed periodically after joining.

In addition to your base salary, you may be eligible for a performance-based bonus, depending on certain performance parameters.

Beyond salary and incentives, the rewards of being part of our team include a variety of competitive benefits such as insurance plans, retirement plans, wellbeing resources, and global recognition programs. We also offer flexible and hybrid working options where possible and a minimum of 14 weeks of paid parental leave.

Pay equity is a fundamental principle of our employment policy, reflecting our commitment to creating a diverse, equitable, and inclusive environment that treats all employees with dignity and respect.

To learn more about our global total rewards offerings, please visit our brochure.

Commitment to Diversity and Inclusion

Novartis is dedicated to developing an outstanding, inclusive work environment and diverse teams that reflect the patients and communities we serve.

Accessibility and Accommodation

Novartis is committed to working with and providing reasonable accommodation to all individuals. If, due to a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process or wish to receive more detailed information about the essential functions of a position, please reach out via email, including the job requisition number in your message.

Why Novartis

Helping people with diseases and their families requires more than innovative science; it involves a community of intelligent, passionate individuals. Together, we collaborate, support, and inspire each other to achieve breakthroughs that change patients' lives. Ready to create a brighter future together? Learn more.

Application Process

Apply online using the form below. Only applications matching the job profile will be considered.