Job ID
REQ-10055008
Date Posted
Jul 15, 2025
Location
Basel, Switzerland
Position Type
Onsite, full-time, #LI-onsite
Summary
We are seeking a dedicated, innovative, and skilled neuroscientist to apply their research experience in neurodegenerative diseases. The focus will be on studying age-related pathophysiological changes in the central nervous system (CNS) that lead to progressive structural and functional decline. Join our dynamic global research environment to contribute to the discovery of new medicines targeting neurodegenerative diseases associated with aging.
About the Role
Our vision is to pioneer the development of novel therapeutic approaches based on the understanding that age is the greatest risk factor for neurodegeneration and related functional decline.
The ideal candidate will have a robust background in neurodegenerative diseases, particularly Alzheimer’s disease, and experience in translational aspects of human pathophysiology utilizing rodent model systems (in vivo/ex vivo). Within the Diseases of Aging and Regenerative Medicine (DARe) area of Biomedical Research, you will contribute to elucidating and targeting molecular mechanisms of neurodegenerative diseases to develop pharmacological interventions for patients.
This role requires strong collaboration across the DARe In-vivo Physiology, In-vitro Biology, and Data Science teams, as well as cooperation with scientists in the Neuroscience disease area to drive our research goals forward.
Major Accountabilities
Your responsibilities include, but are not limited to:
- Managing a small in vivo laboratory team, designing, and conducting state-of-the-art in-vivo mouse and rat experiments to support research aimed at developing novel therapeutics for age-related neurodegenerative diseases, with a particular focus on Alzheimer’s disease.
- Mentoring and supporting the career development of direct reports.
- Conducting cutting-edge research on pathophysiological changes in neurons and other CNS cell types, including synaptic dysfunction and metabolic changes related to aging and disease.
- Collaborating at the interface between in vitro biology, integrated pharmacology, aging, and disease research to deliver new and actionable therapeutic targets to develop innovative medicines addressing neurodegeneration.
- Supporting the identification of biomarker candidates, elucidating the mode of action of drugs, and understanding cross-talk between CNS cell types and across brain subregions, as well as with other organs, to delineate disease trajectories and novel drug intervention strategies.
- Integrating laboratory research of in vitro, in vivo, and ex vivo tissue and biofluid analyses while applying a broad range of molecular and cellular techniques.
- Interpreting and presenting results effectively in both written and oral formats at project team meetings and to management decision boards.
What You'll Bring to the Role
Essential:
- A PhD with 3+ years of post-doctoral research in neuroscience, with hands-on experience in designing and conducting experiments with rodents, documented through publications.
- Accreditation for animal experimentation (LTK1/LTK2, FELASA B, or equivalent).
- Deep knowledge of human and animal pathophysiology related to neurodegenerative diseases, including Alzheimer’s disease. Additional expertise in neuro-endocrine systems, metabolism, and CNS tissue homeostasis is advantageous.
- Proficiency in handling and analyzing large datasets and integrating genomic, proteomic, and metabolomic data into research.
- A strong motivation to learn more about targeting neurodegenerative diseases of aging and regenerative medicine.
- A proactive and dynamic attitude, with a demonstrable inquisitive mindset and a proven ability to formulate, articulate, and critically evaluate scientific experiments.
- Excellent teamwork skills and the ability to thrive in cross-disciplinary teams, demonstrating high learning agility and a desire to stay up to date with the latest in vivo methodologies.
- Fluency in written and oral English, with excellent communication skills.
Desirable Requirements:
- Knowledge of aging biology.
- Experience in assessing pathophysiological cross-talk between different CNS cell types and CNS subregions, as well as with peripheral organs.
Accessibility and Accommodation
Novartis is committed to working with and providing reasonable accommodations to all individuals. If you need a reasonable accommodation for any part of the recruitment process due to a medical condition or disability, please contact us. Include your request along with your contact information and the job requisition number.
Why Novartis
Helping people with diseases and their families involves more than just innovative science. It requires a community of intelligent, passionate individuals collaborating, supporting, and inspiring each other. Are you ready to create a brighter future together?
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Benefits and Rewards
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Application Process
Apply online using the form below. Only applications that match the job profile will be considered.
Division
Biomedical Research
Business Unit
Pharma Research
Employment Type
Full-time
Shift Work
No