Postdoctoral Researcher / Postdoctoral Researcheress in 3D Imaging and Organ-on-Chip Models of Human Lung Lymphatics

Postdoctoral Position: 3D Imaging and Organ-on-Chip Models of Human Lung Lymphatics

100%, Zurich, fixed-term

The Halin Lab at ETH Zürich is at the forefront of research investigating the intersection of immunology and lymphatic vascular biology. Utilizing advanced microscopy and transcriptomic approaches, we explore lymphatic morphology and leukocyte migration. We invite applications for a postdoctoral researcher to delve into the structure and function of human pulmonary lymphatic networks in both healthy and chronic lung disease contexts.

Project Background

This project, funded by the Swiss National Science Foundation (SNSF) in collaboration with the University of Bern, employs advanced 3D microscopy, organ-on-chip technology, and mechanobiological methods to analyze lymphatic remodeling and immune cell dynamics in chronic obstructive pulmonary disease (COPD).

Job Description

As a postdoctoral researcher, you will:

• Collaborate with partners in Bern to develop multi-compartment organ-on-chip systems that integrate lymphatic and vascular networks under physiologically relevant mechanical conditions.
• Apply your expertise in lymphatic vascular biology to characterize these networks in terms of morphology (e.g., junctional organization) and function.
• Utilize the models to investigate lymphangiogenesis, immune cell recruitment, and lymphatic drainage under steady-state and COPD-like inflammatory conditions.
• Examine 3D lymphatic and blood vascular networks in healthy and COPD human lung tissues using light-sheet and confocal microscopy.
• Contribute to the teaching and supervision of Master’s students at ETH.

Profile

We are seeking a highly motivated postdoctoral researcher with a robust background in vascular or lymphatic biology. We value enthusiasm for interdisciplinary science and a strong commitment to collaborative research.

Requirements:

• PhD in Vascular Biology, Cell Biology, Mechanobiology, or a related field.
• Solid expertise in vascular biology, ideally complemented by knowledge of mechanobiology and microfluidic engineering.
• Excellent microscopy skills (confocal, multiphoton, and ideally light-sheet imaging).
• Hands-on experience with primary endothelial cell culture and standard molecular techniques (flow cytometry, Western blot, qPCR, ELISA).
• Experience working with organ-on-chip or microphysiological systems is a plus.
• First-author publication(s) in peer-reviewed journals (published or submitted).
• Excellent oral and written communication skills in English.
• Ability to independently develop and drive a research project while collaborating within a multidisciplinary team.

Workplace

You will join a stimulating, supportive, and international research environment at the Institute of Pharmaceutical Sciences at ETH Zürich.

We Offer

• A dynamic research environment supported by state-of-the-art facilities and technologies, including advanced imaging and molecular platforms.
• Collaboration with multidisciplinary teams and clinician scientists at the University of Bern.
• The opportunity to contribute to innovative translational research at the intersection of vascular biology, immunology, respiratory medicine, and microfluidic engineering.
• A competitive salary and employment conditions in accordance with ETH Zürich and SNSF regulations (project funded for 4 years).

We Value Diversity and Sustainability

At ETH Zurich, we are committed to fostering an inclusive culture that promotes equality of opportunity and values diversity. We strive to create a working and learning environment where the rights and dignity of all staff and students are respected. Sustainability is a core value for us as we work towards a climate-neutral future.

Curious? So Are We.

The position will remain posted until it is filled. Apply online using the form below. Please note that only applications matching the job profile will be considered.

For further information about our institute, you can visit our website. For scientific inquiries, please contact Prof. Dr. Cornelia Halin Winter via email at cornelia.halin@pharma.ethz.ch.

Collaborating Groups:

• ARTORG Center - Organ-on-Chip Technologies (Prof. Guenat)
• Institute of Pharmacology - Bourquin Lab

About ETH Zürich

ETH Zurich is one of the world's leading universities specialized in science and technology, renowned for its excellent education, advanced research, and direct transfer of knowledge into society. We welcome over 30,000 individuals from more than 120 countries, fostering independent thinking and a culture of excellence. Located in the heart of Europe, we are committed to addressing global challenges through collaborative and innovative solutions.