Postdoctoral Researcher / Postdoctoral Researcheress in Biological and Molecular Systems on CMOS Sensing/Actuating Platforms

Postdoctoral Position: Biological and Molecular Systems on CMOS Sensing/Actuating Platforms

100%, Zurich, fixed-term

The Integrated Devices, Electronics, And Systems (IDEAS) Group, led by Prof. Dr. Hua Wang at ETH Zurich, invites applications for a postdoctoral position focusing on biological and molecular assays and bio-experiments for bioelectronics and biosensors using CMOS (Complementary Metal-Oxide-Semiconductor) integrated circuit (IC) chips.

The scope of this position combines molecular and electrochemical assays with cell biology on micro-/nano-electronic devices. The aim is to develop molecular assays (genomics and proteomics) and cellular assays while supporting experimental work across a range of CMOS bioelectronics and biosensor projects. Please note that this position is NOT for electronic circuits research.

Project Background

Living cells, such as neurons, are complex biological systems with dynamic, multi-functional behaviors honed by billions of years of evolution. Interfacing with living cells using advanced micro-/nano-electronics opens new avenues for sensing and actuation but necessitates robust biological protocols and stable bioelectronic interfaces.

Simultaneously, biomolecules and their complexes can be manipulated using CMOS micro-/nano-electronics, enabling applications like molecular sensing (DNA/proteins), surface functionalization, electrochemical reactions, and molecular synthesis.

Our ETH IDEAS group has developed multiple generations of CMOS cellular/molecular platforms featuring dense arrays of electrodes and multi-modal active pixels for effective sensing and actuation. These platforms emphasize long-term culture and sensing of biological systems, including neurons, human stem-cell-derived cells, and animal-based cells, while also focusing on molecular or chemical functionalities, such as electrochemical measurements and on-chip molecular processes.

A central requirement across these diverse projects is bio-experimental expertise in both cellular and molecular/electrochemical workflows. This postdoctoral position supports research across these applications and contributes to the development and operation of CMOS bioelectronics and biosensors at the ETH IDEAS group.

Job Description

You will work on the molecular and cellular assays and systems for CMOS bioelectronics and biosensor platforms. Please note that this position is NOT for CMOS electronic circuit research.

• Long-term culture and maintenance of neurons and other cell-based assays on CMOS integrated circuit (IC) chips
• Collaboration with human stem-cell-derived cells, animal-based cells, and other cellular systems for extended-time cell culture and interfacing experiments on CMOS
• Development and maintenance of stable and reproducible cell-microelectrode interfaces on CMOS
• Design and execution of molecular and electrochemical experiments on CMOS micro-/nano-electrode arrays, including surface functionalization and electrodeposition
• Implementation of molecular and chemical workflows on CMOS IC chips, including electrochemical reactions and molecular synthesis
• Biological and molecular characterization using microscopy, fluorescence-based assays, and electrochemical measurements
• Collaboration with CMOS electronics researchers to support experimental design and platform operation
• Contribution to teaching activities, including lectures, exercises, or laboratory components related to cellular/molecular biology
• Presentation of results at internal meetings and international conferences
• Preparation of peer-reviewed publications
• The position offers scientific freedom to shape experimental workflows and contribute to multiple projects within a highly interdisciplinary research environment at ETH Zurich

Profile

• PhD degree or equivalent in cell biology, molecular biology, neuroscience, chemistry, electrochemistry, bioengineering, biomedical engineering, or closely related disciplines
• Experience in long-term cell cultures, particularly neuronal cultures
• Experience with cellular assays using human stem-cell-derived cells and/or animal-based cells
• Strong experimental background in molecular chemistry, electrochemistry, or related chemical systems
• Experience with bioelectronic platforms, microelectrode arrays, or Organ-on-Chip systems is an advantage
• Strong interest in interdisciplinary research involving biological and molecular systems on CMOS bioelectronics and biosensors
• Strong interest in contributing to teaching and mentoring
• Excellent work ethics, scientific rigor, and an ability to build collaborative team cultures
• Ability to work independently as well as part of a team
• Excellent organizational skills and high reliability
• Proven track record in scientific work, communication, and publications
• Fluent oral and written communication skills in English are essential

Workplace

ETH Zurich provides a collaborative research environment with access to state-of-the-art biological and chemical laboratories, equipment, and CMOS IC platforms.

We Offer

• A new research frontier with a highly interdisciplinary nature at the interface of biology, molecular systems, and CMOS bioelectronics/biosensors
• Collaboration within ETH Zurich and extended partnerships with UZH, EPFL, EMPA, PSI, and industry in Switzerland
• Opportunities to gain teaching experience in an interdisciplinary graduate-level course
• Support benefits including professional networking and career development opportunities
• Regular seminars and symposia within the ETH Zurich research ecosystem
• A fully funded position for an initial period of 1-2 years, with the possibility of extension contingent on performance and available funding

We Value Diversity and Sustainability

ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity, and nurture an environment in which the rights and dignity of all staff and students are respected. Sustainability is a core value for us as we work towards a climate-neutral future.

Curious? So are We!

We look forward to receiving your application online using the form below. Please ensure to include the following documents:

• Cover letter outlining your motivation and experience
• Concise CV
• Diploma and certificates
• Five of your best publications

For more information about the IDEAS Group, visit our website. Questions regarding the position should be directed to ideas-jobs@iis.ee.ethz.ch (no applications).

Only applications matching the job profile will be considered.

About ETH Zurich

ETH Zurich is one of the world's leading universities specializing in science and technology. We are renowned for our excellent education, cutting-edge fundamental research, and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place encouraging independent thought and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.