Postdoctoral Researcher / Postdoctoral Researcheress

Postdoc Position - Developing Novel Ways to Control Viruses for Targeted Infection of Cellular Systems

100%, Basel, fixed-term

The highly competitive Bio-Engineering Systems for Therapeutics (BEST) postdoc programme, part of the Next-gen Bioengineers initiative, is operated jointly by the Department of Biosystems Science and Engineering of ETH Zurich and Roche Pharma Research and Early Development (pRED). The programme focuses on developing new tools and methods to address existing challenges and develop solutions for future needs in medical translation and therapeutics.

Project Background

Viral vector-based gene therapies are extensively explored in preclinical and clinical development for treating genetic diseases by infecting targeted cells. However, enhancing the target cell specificity of viral vectors, known as tropism, is an ongoing and crucial endeavor in the field of gene therapy. Viral infection is initiated when a virus binds to cell surface receptors with specific thermodynamic and kinetic on/off rates at equilibrium, which can act as a limiting factor for optimizing viral tropism. In this collaborative project, we aim to explore innovative ways to adjust this equilibrium to control the on/off rates of viral vectors in proximity to target cells, tissues, and organoids. We will utilize multiparametric approaches to quantify the interactions (on/off rates) of a specific set of viruses with various cellular systems, including cultured cells, organoids, tissues, and organs. Ultimately, our goal is to characterize the parameters that influence thermodynamic and kinetic on/off rates and viral tropism. This quantitative approach will open new avenues for engineering and controlling the on/off equilibrium of viral vectors, moving beyond traditional genetic modifications. We anticipate that this study will contribute to increasing transduction efficiency and viral tropism, paving the way for successful viral gene therapy.

Job Description

This position involves independent research on an interdisciplinary project at the highest scientific levels across two prominent locations: the Department of Biosystems Science and Engineering at ETH Zurich and the Department of Ophthalmology at pRED, Roche, both situated in the vibrant City of Basel.

Profile

• PhD degree or equivalent in biology, biotechnology, biophysics, biomedicine, biomedical engineering, biochemistry, gene-based delivery methods, pharmacy, or related disciplines.
• Interest in training within ophthalmology, neurobiology, biophysics, bionanotechnology, virus engineering, and cell and tissue biology.
• Enthusiasm for interdisciplinary research at the Roche and ETH Zurich campuses in Basel.
• Previous experience in cell biology, nanotechnology, gene therapy, and biophysics is advantageous.
• Ability to work independently as well as collaboratively within a team; excellent organizational skills and high reliability.
• Proven track record in scientific work, communication, and publication.
• Outstanding capability to contribute independently within highly collaborative teams.
• Fluent oral and written communication skills in English are essential.

Workplace

ETH Zurich and Roche provide an inspiring working environment, fostering innovation and research collaboration that impacts global challenges.

We Offer

• Exciting and highly innovative collaborative research within the framework of Biosystems Engineering for Medical Translation.
• Co-supervision by leading investigators from ETH Zurich and Roche.
• Full access to the facilities and expertise at both campuses.
• Support programme benefits, including networking and career development opportunities.
• Regular seminars and joint symposia at ETH Zurich and Roche.
• A fully funded fellowship for an initial duration of two years.

We Value Diversity and Sustainability

In line with our core values, ETH Zurich fosters an inclusive culture. We promote equality of opportunity, value diversity, and nurture a work and learning environment that respects the rights and dignity of all staff and students. Sustainability is fundamental to our values, and we are actively working towards a climate-neutral future.

Interested?

We invite you to apply online using the form below with the following documents as a single PDF:

• A letter of motivation
• CV including a list of publications
• Two letters of recommendation
• A brief statement of research interests (1500 characters)
• A copy of your original doctoral degree certificate

Application Deadline: Applications can be submitted until January 1, 2026, with evaluations being conducted on a rolling basis. Only applications matching the job profile will be considered.

If you have questions regarding the position, please reach out to Prof. Dr. Daniel J. Müller at daniel.mueller@bsse.ethz.ch and/or Prof. Dr. Sascha Fauser at sascha.fauser@roche.com (no applications).

Further information about the Biophysics Group at ETH Zurich D-BSSE and the division of ophthalmology at Roche pRED can be found on their respective websites. You can access more information about the Next-gen Bioengineers postdoc programme on the website.

About ETH Zurich

ETH Zurich is one of the world’s leading universities specializing in science and technology. Renowned for its excellent education, cutting-edge research, and efficient knowledge transfer to society, ETH Zurich is home to over 30,000 individuals from more than 120 countries. Our university is a hub for independent thought and a nurturing environment that inspires excellence. Located in the heart of Europe, we are committed to forging connections worldwide to develop solutions to today’s and tomorrow’s global challenges.