Postdoctoral Researcher in Development of in vitro Skin Model including Sensory Perception / Postdoctoral Researcheress in Development of in vitro Skin Model including Sensory Perception

Postdoc Position in the Development of In Vitro Skin Models Including Sensory Perception

100%, Basel, fixed-term

For a collaboration project between the Bio Engineering Laboratory (Department of Biosystems Science and Engineering of ETH Zurich in Basel) and Novartis AG, Basel, Switzerland, we are seeking a highly motivated and enthusiastic Postdoc. You will have a unique opportunity to collaborate across scientific and organizational boundaries, focusing on developing advanced skin models to study barrier function and itching. These models have the potential for therapeutic breakthroughs for patients.

Project Background

Leveraging cutting-edge advanced cellular models and bioengineering and microfluidic approaches, this project aims to develop skin models that include sensory perception for understanding immunological skin diseases and applications in drug discovery. Current ex vivo skin models, although widely used in pharmaceutical and cosmetic research, fall short in assessing, in real-time, itch-inducing and barrier-compromising conditions. Emerging models based on primary keratinocytes and induced pluripotent stem cells (iPSC) can better replicate physiological and disease conditions. However, such models need adaptation for pharmaceutical research and target identification.

Job Description

• In this collaborative effort, you will devise an in vitro 3D human skin model to investigate barrier function under homeostatic conditions and in response to inflammatory stimuli.
• By combining state-of-the-art engineering and microfluidic approaches with new cellular models, you will develop innovative skin models that include sensory perception, applicable in fundamental science and drug testing.
• Your dual role will involve setting up and culturing the 3D skin models and optimizing sensor technology (e.g., TEER and TEWL) to enable a robust assessment of skin barrier functionality.
• Additionally, itch perception will be studied by integrating iPSC-derived sensory neurons.

Profile

• We are looking for a candidate with a strong background in biology and engineering (e.g., bioengineering, biotechnology, or related fields), possessing solid knowledge of molecular biology and cell culturing, preferably in microphysiological systems.
• Important experience includes primary cell culturing, working with advanced in vitro models, epithelial/endothelial barrier characterization, and iPSC differentiation. Skills in optical microscopy, sensor development and integration, as well as electrophysiology are a plus.
• Academic excellence, a professional attitude, and a self-driven nature are expected.
• Strong communication skills, fluency in English, and a proactive mindset are essential for thriving in this collaborative, international environment.

Workplace

The position is fully funded for an initial duration of 2 years, with the possibility of extension up to 4 years. The starting date is flexible but must be before June 2026.

We Offer

• Your job with impact: Become part of ETH Zurich, which not only supports your professional development but also actively contributes to positive change in society.
• You can expect numerous benefits, such as public transport season tickets and car sharing, a wide range of sports offered by the ASVZ, childcare, and attractive pension benefits.

We Value Diversity and Sustainability

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity, and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Sustainability is a core value for us; we are consistently working towards a climate-neutral future.

Curious? So Are We.

We look forward to receiving your online application. Please apply online using the form below. Only applications matching the job profile will be considered.

For further information about the Bio Engineering Laboratory, please visit our website. For inquiries regarding the position, contact us exclusively via email at mario.modena@bsse.ethz.ch.

About ETH Zurich

ETH Zurich is one of the world's leading universities specializing in science and technology. We are renowned for our excellent education, cutting-edge fundamental research, and the direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and inspiring excellence. Located in the heart of Europe yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.