Postdoctoral Researcher in Development of in vitro Skin Model Including Sensory Perception

Postdoc Position in Development of In Vitro Skin Model Including Sensory Perception

100%, Basel, Fixed-term

We are excited to announce a unique opportunity for a highly motivated and enthusiastic Postdoc within a collaboration project between the Bio Engineering Laboratory (Department of Biosystems Science and Engineering of ETH Zurich in Basel) and Novartis AG, Basel, Switzerland. This role focuses on developing advanced skin models to study barrier function and itching, which have the potential for therapeutic breakthroughs for patients.

Project Background

The project aims to leverage cutting-edge advanced cellular models, bioengineering, and microfluidic approaches. The objective is to develop skin models that incorporate sensory perception to better understand immunological skin diseases and applications in drug discovery. Current ex vivo skin models, while commonly used in pharmaceutical and cosmetic research, do not adequately assess itch-inducing and barrier-compromising conditions in real-time. Emerging models based on primary keratinocytes and induced pluripotent stem cells (iPSCs) are poised to more accurately replicate physiological and disease conditions, necessitating adaptation for pharmaceutical research and target identification.

Job Description

• Devise an in vitro 3D human skin model to investigate barrier function under homeostatic conditions and in response to inflammatory stimuli.
• Combine state-of-the-art engineering and microfluidic approaches with new cellular models to develop innovative skin models that encompass sensory perception for applications in fundamental science and drug testing.
• Set up and culture the 3D skin models while optimizing sensor technology (e.g., TEER and TEWL) to enable robust assessment of skin barrier functionality.
• Investigate itch perception through the integration of iPSC-derived sensory neurons.

Profile

• A strong background in biology and engineering (e.g., bioengineering, biotechnology, or related fields) with a solid knowledge of molecular biology and cell culturing, preferably in microphysiological systems.
• Experience in primary cell culturing, work with advanced in vitro models, epithelial/endothelial barrier characterization, and iPSC differentiation; skills in optical microscopy, sensor development, and integration, as well as in electrophysiology, are advantageous.
• Academic excellence, a professional attitude, and a self-driven nature are expected.
• Strong communication skills, fluency in English, and a proactive mindset are essential for thriving in this collaborative international environment.

Workplace

ETH Zurich is committed to fostering a dynamic workplace that nurtures the professional and personal growth of its employees.

We Offer

• Transformative work: Join ETH Zurich and contribute to positive societal change while advancing your professional development.
• A comprehensive benefits package, including public transport season tickets, car sharing, a variety of sports activities offered by our sports association (ASVZ), childcare, and attractive pension benefits.

Commitment to Diversity and Sustainability

ETH Zurich promotes an inclusive culture that respects and values diversity. We are dedicated to providing equal opportunities and nurturing a working environment where the rights and dignity of all our staff and students are upheld. Sustainability is a core value for us—we are consistently striving towards a climate-neutral future.

Curious? So Are We.

We look forward to receiving your online application using the form below. Please note that only applications matching the job profile will be considered.

About ETH Zurich

ETH Zurich is one of the world's leading universities specializing in science and technology. We are renowned for our excellent education, cutting-edge research, and direct transfer of new knowledge into society. Over 30,000 individuals from more than 120 countries regard our university as a place that fosters independent thinking and inspires excellence. Located in the heart of Europe and forging connections globally, we work collaboratively to develop solutions for today's and tomorrow's global challenges.