Postdoc in Development of in vitro Skin Model Including Sensory Perception / Postdoc in Development of in vitro Skin Model Including Sensory Perception (Female)

Postdoc Position in Development of In Vitro Skin Model Including Sensory Perception

100%, Basel, fixed-term

For a collaborative project between the Bio Engineering Laboratory of ETH Zurich in Basel and Novartis AG, we are seeking a highly motivated and enthusiastic Postdoc. This role offers a unique opportunity to work across scientific and organizational boundaries, focusing on the development of advanced skin models that study barrier function and itching, with the potential for therapeutic breakthroughs for patients.

Project Background

Leveraging cutting-edge cellular models, bioengineering, and microfluidic approaches, this project aims to develop skin models that incorporate sensory perception. These models will enhance the understanding of immunological skin diseases and will be applicable in drug discovery. Current ex vivo skin models, while widely used in pharmaceutical and cosmetic research, often fall short in assessing real-time itch-inducing and barrier-compromising conditions. Emerging models based on primary keratinocytes and induced pluripotent stem cells (iPSCs) have the potential to better replicate physiological and disease conditions, necessitating further adaptation for pharmaceutical research and target identification.

Job Description

• Devise an in vitro 3D human skin model to investigate barrier function under homeostatic conditions and in response to inflammatory stimuli.
• Combine state-of-the-art engineering and microfluidic approaches with new cellular models to create skin models that include sensory perception, applicable in fundamental science and drug testing.
• Assume a dual role in setting up and culturing the 3D skin models and optimizing sensor technology (e.g., TEER and TEWL) for a robust assessment of skin barrier functionality.
• Study itch perception by integrating iPSC-derived sensory neurons.

Profile

• A strong background in biology and engineering (e.g., bioengineering, biotechnology, or related fields) with solid knowledge of molecular biology and cell culture, preferably in microphysiological systems.
• Important experience includes primary cell culturing, work with advanced in vitro models, epithelial/endothelial barrier characterization, and iPSC differentiation; skills in optical microscopy, sensor development and integration, as well as electrophysiology are a plus.
• Academic excellence, a professional attitude, and a self-driven nature are expected.
• Strong communication skills, fluency in English, and a proactive mindset are essential for thriving in this collaborative, international environment.

Employment Details

This position is fully funded for an initial period of 2 years, with a possibility of extension up to 4 years. The starting date is flexible but must be before June 2026.

Workplace

Join us within a dynamic and innovative setting that fosters collaboration and research excellence.

We Offer

• Your job with impact: Become part of ETH Zurich, which supports your professional development and actively contributes to positive change in society.
• Numerous benefits, including public transport season tickets, car sharing options, a variety of sports offered by ASVZ, childcare services, and attractive pension benefits.

We Value Diversity and Sustainability

In alignment with our values, ETH Zurich fosters an inclusive culture. We promote equality of opportunity, value diversity, and nurture a working and learning environment that respects the rights and dignity of all staff and students. Explore our Equal Opportunities and Diversity website to learn how we ensure a fair and open environment that allows everyone to thrive. Sustainability is one of our core values, and we are committed to working towards a climate-neutral future.

Curious? So Are We.

We look forward to receiving your online application. Please apply online using the form below.

Note: Only applications matching the job profile will be considered.

About ETH Zurich

ETH Zurich is one of the world's leading universities specializing in science and technology. We are renowned for excellent education, pioneering fundamental research, and the direct transfer of new knowledge into society. With over 30,000 people from more than 120 countries, our university promotes independent thinking and inspires excellence. Located in the heart of Europe and forging connections globally, we work collaboratively to address today’s and tomorrow’s global challenges.