PhD Student in Stomatal Immunity and Metabolism / PhD Studentess in Stomatal Immunity and Metabolism

PhD Student Position in Stomatal Immunity and Metabolism

100%, Zurich, fixed-term

The Plant Molecular Physiology lab at ETH Zurich is seeking a highly motivated PhD student to join our research team on a project focused on stomatal immunity and metabolism. Stomata are tiny pores on the leaf surface that regulate gas exchange and plant productivity while also serving as natural entry points for both plant and human pathogens. Although stomata respond rapidly to microbial signals by closing, the underlying metabolic mechanisms that facilitate this response remain poorly understood. This project aims to uncover how immune signaling reprograms metabolism in guard cells, leading to stomatal closure and limiting pathogen entry.

Job Description

Research Focus:

• Molecular genetics in Arabidopsis to dissect key signaling components linking immune perception to metabolic regulation.
• Phosphoproteomics and targeted metabolite analysis to identify metabolic switches activated during microbial exposure.
• Comparative genome editing experiments in lettuce to translate mechanistic insights from Arabidopsis into an agriculturally relevant crop system.

The student will investigate how microbial elicitors trigger specific metabolic adjustments in guard cells, how these changes influence ion fluxes and osmotic regulation, and how pathogens may circumvent these defenses. The project will integrate aspects of cell biology, biochemistry, plant immunity, and translational crop research.

The long-term goal is to identify metabolic control points that can be leveraged to enhance natural plant defenses and minimize pathogen entry into leafy vegetables, contributing to sustainable agriculture and improved food safety.

Profile

Qualifications:

• A Master's degree in Molecular Biology, Plant Biology, Biochemistry, or a related field.
• Strong interest in plant molecular mechanisms and cellular regulation.
• Experience with molecular biology techniques and/or plant genetics.
• Motivation to work independently while contributing to a collaborative research environment.
• Excellent communication skills in English.
• Experience in Arabidopsis, microscopy, or omics approaches is an advantage but not required.

Responsibilities:

• Conduct independent research under the supervision of senior researchers.
• Design and perform experiments, analyze data, and interpret results.
• Prepare and present research findings at scientific conferences and in peer-reviewed journals.
• Collaborate with other team members and contribute to the overall research goals.

Workplace

The working environment is dynamic and supportive, providing access to state-of-the-art facilities at ETH Zurich. The student will receive training in advanced molecular, biochemical, and imaging approaches, and will be integrated into a vibrant international plant science community. This position offers the opportunity to contribute to research with significant societal impact in sustainable agriculture and food safety.

We Value Diversity and Sustainability

ETH Zurich is committed to fostering an inclusive culture and promoting equality of opportunity. We value diversity and are dedicated to creating a working and learning environment where the rights and dignity of all staff and students are respected. Sustainability is a core value; we are consistently working towards a climate-neutral future.

Curious? So Are We.

If you're excited about this opportunity, please apply online using the form below. Only applications matching the job profile will be considered.

Further Information:

Further information about the Plant Molecular Physiology lab can be found on our website. Questions regarding the position should be directed to Diana Santelia via email at dsantelia@ethz.ch (no applications).

About ETH Zurich

ETH Zurich is one of the world’s leading universities specializing in science and technology. With a reputation for excellent education, cutting-edge fundamental research, and the direct transfer of new knowledge into society, we are home to over 30,000 people from more than 120 countries. Our university promotes independent thinking and inspires excellence, forging connections globally while working to develop solutions for today’s and tomorrow’s challenges.