PhD Position in Peptide-Based Drug Discovery (Industry Collaboration, w/m/d)

ETH Zurich - June 19, 2025

PhD Position in Peptide-Based Drug Discovery (Industry Collaboration, w/m/d)

100%, Zurich, fixed-term

The Research Group for Peptide-Based Drug Discovery (Prof. Nathalie M. Grob) at ETH Zürich, in collaboration with Novo Nordisk in Copenhagen, Denmark, is seeking an exceptional and highly motivated PhD candidate for a joint project. We are recruiting a full-time (100%) PhD Student with a strong interest in peptide chemistry, mass spectrometry, and modern drug discovery to establish an innovative platform for peptide drug discovery.

Project Background

Peptides are recognized as privileged modalities for the development of new therapeutic strategies. The discovery of bioactive peptides aimed at addressing unexploited targets and offering alternative therapeutic strategies on established disease pathways represents a fundamental challenge. This project emphasizes the development of novel technologies for hit identification and validation, with a focus on achieving high experimental throughput and success rates.

Job Description

The four-year project is co-funded by Novo Nordisk and will be supervised by Prof. Nathalie Grob (ETHZ) in cooperation with Novo Nordisk, providing a unique opportunity to work at the intersection of academia and industry. This project leverages cutting-edge technology to make a real-world impact in peptide drug discovery. Short research visits (3 months) at the Novo Nordisk research site in Copenhagen and access to high-throughput instrumentation are planned throughout the project. Candidates with prior experience in peptide synthesis, mammalian tissue culture, and mass spectrometry will find this advantageous.

To contribute to the project's success, the candidate will integrate into a multidisciplinary team that effectively combines independent work with collaborative discussions. Responsibilities will include:

  • Chemical synthesis of peptides
  • Experimental development of drug discovery technology
  • Biophysical and cellular evaluation of bioactivity

Profile

The ideal candidate will hold a recently completed MSc degree or equivalent in Chemistry, Pharmacy, Pharmaceutical Sciences, Chemical Biology, Cellular Biology, or related disciplines. Relevant experience in several of the following areas is preferred:

  • Peptide synthesis
  • Mammalian cell culture
  • Protein biochemistry
  • Mass spectrometry
  • Bioinformatics and programming

The successful applicant will possess a genuine passion for science and collaboration, coupled with a strong motivation and intrinsic interest in drug discovery and development. Effective communication skills in English are essential as the working language in a multidisciplinary environment.

The candidate must be available to start the project by 01 October 2025. Additionally, it is required that the candidate has authorization to work in Switzerland and can travel to Denmark for short-term projects (under 3 months) without the need for additional permits.

Workplace

Join a vibrant research community in a dynamic and innovative academic environment.

We Offer

  • Collaborative project: Experience the synergy of working closely with academic and industrial partners.
  • Your job with impact: Become part of ETH Zurich, contributing to professional development and positive societal change.
  • Commitment to sustainability: We actively promote a sustainable and climate-neutral university.
  • Numerous benefits: Enjoy perks such as public transport season tickets, car sharing, access to diverse sports programs, childcare, and attractive pension benefits.

We Value Diversity

In line with our values, ETH Zurich fosters an inclusive culture. We promote equality of opportunity, value diversity, and create a working and learning environment that respects the rights and dignity of all staff and students. Visit our Equal Opportunities and Diversity website to learn more about how we ensure a fair and open environment that allows everyone to thrive.

Curious? So Are We.

Apply online using the form below. Only applications matching the job profile will be considered.

For any questions regarding the position, please contact Prof. Nathalie M. Grob at Tel [] or email [].

About ETH Zürich

ETH Zurich is one of the world’s leading universities specializing in science and technology, recognized for its outstanding education, pioneering research, and direct transfer of knowledge to society. With over 30,000 individuals from more than 120 countries, our university promotes independent thinking and fosters an environment that inspires excellence. Situated in the heart of Europe while forming global connections, we work collaboratively to develop solutions for today’s and tomorrow's challenges.

Location : Zürich
Country : Switzerland

Application Form

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