PhD Position in Immunology & Biomaterials / PhD Position in Immunology & Biomaterials

PhD Position in Immunology & Biomaterials

100%, Zurich, fixed-term

We invite applications for a fully funded PhD position in the Zindel Lab (Department of Biology, ETH Zurich), in close collaboration with the Tibbitt Lab (Department of Mechanical and Process Engineering, ETH Zurich). This interdisciplinary project investigates how the immune system responds to implanted materials, aiming to develop strategies that improve tissue integration and patient outcomes. The work will combine in vivo biology and advanced imaging with materials science and polymer engineering.

Project Background

The Hydrophobic Effect as a Danger Signal in Foreign Body Biology

Implantable medical devices such as joint replacements, hernia meshes, and intraocular lenses are central to modern medicine. Yet, many implants still trigger inflammation and scarring, shortening their functional lifetime.

This PhD project addresses a fundamental question: Does hydrophobicity act as a universal immune danger signal? Using animal models, primary human cell systems, and multiphoton microscopy, you will explore the molecular and cellular mechanisms of foreign body reactions. In parallel, you will collaborate with engineers to design and test microgels with tunable surface properties, linking materials chemistry to immune recognition and tissue repair.

Job Description

• Perform experimental biology in the Zindel Lab, including surgical in vivo mouse models and cutting-edge intravital multiphoton imaging.
• Fabricate and characterize new biomaterials in the Tibbitt Lab, developing methods to create microgels with varying degrees of hydrophilicity, typically with diameters on the order of tens of microns.
• Investigate innate immune responses at cellular and molecular levels to various biomaterial properties.
• Develop skills in soft material fabrication and characterization, mechanical characterization, chemical formulation, bioconjugate chemistry, fluorophore labeling, and fluorescence imaging.
• Integrate biological and engineering insights to develop mechanistic models of implant integration.

Profile

• A strong passion for both biomedical research and materials engineering; you may be a biologist eager to explore materials science or a materials scientist excited to dive into immune biology.
• A Master’s degree in a relevant field is required.
• A strong interest in immunology, tissue regeneration, and translational medicine.
• Prior experience with animal models is advantageous; a willingness to perform animal work is essential.
• Motivation to learn materials fabrication and characterization through collaboration.
• Enthusiasm for working in an interdisciplinary, international research environment.

Workplace

You will be based in the Zindel Lab (D-BIOL, Campus Hönggerberg) with supervision by Prof. Zindel, a former surgeon-scientist focused on immunology and tissue regeneration. You will collaborate closely with the Tibbitt Lab (D-MAVT, Campus Zentrum) under the co-supervision of Prof. Tibbitt, gaining complementary expertise in macromolecular engineering and characterization.

We Offer

• A supportive, interdisciplinary training environment with access to state-of-the-art facilities in imaging, biology, and soft material fabrication.
• Integration into SKINTEGRITY.CH, a nationwide network of scientists, engineers, and clinicians.
• The opportunity to contribute to the development of next-generation medical implants designed to improve millions of lives.

We Value Diversity

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity, and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to learn how we ensure a fair and open environment that allows everyone to grow and flourish.

Curious? So Are We.

Apply online using the form below. Please submit the following documents:

• Motivation letter
• CV, including a list of publications
• Master’s diploma with transcript of grades

Only applications matching the job profile will be considered. Questions regarding the position should be directed to Prof. Joel Zindel at joel.zindel@biol.ethz.ch (no applications).

About ETH Zurich

ETH Zurich is one of the world's leading universities specializing in science and technology. We are renowned for our excellent education, cutting-edge fundamental research, and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.