PhD Opening in Bioengineering / PhD Opening in Bioengineering

PhD Opening in Bioengineering: Microfluidic In-vitro Barrier Models for Bacterial Lung and Bladder Infections

Location: Basel, Switzerland | Contract Type: Fixed-term, 100%

The Bio Engineering Laboratory at the Department of Biosystems of ETH Zurich in Basel is inviting applications for a PhD position focusing on the Engineering of Microfluidic In-vitro Barrier Models for Bacterial Lung and Bladder Infections. We are looking for a highly motivated and enthusiastic PhD student to join our dynamic and international team in Basel, Switzerland. This project is part of the large National Competence Center of Research (NCCR) - Antiresist, which brings together clinicians, academic and industrial research partners across multiple disciplines to develop a microfluidic platform for studying bacterial lung and bladder infections and testing new antibacterial drugs.

The platform incorporates a microfluidic system designed for culturing sophisticated in-vitro lung and bladder barrier models (membrane-based organ-on-chip models), while exposing them to bacteria and potential therapeutic compounds. It employs a variety of analytical techniques such as fluorescence microscopy, mass spectroscopy, TEER, and permeability assays to continuously monitor the barrier-layer status and viability.

Job Description

The selected candidate will enhance the microfluidic platform tailored for culturing transwell-based lung and bladder organoid models, collaborating closely with infection biologists from the Biozentrum (University of Basel). Specifically, the platform will be utilized to:

• Investigate mechanisms underlying bacterial infections and the emergence of antimicrobial resistance.
• Assess innovative treatment strategies.

A primary goal is to optimize the platform for translational applications in clinical and industrial settings.

Profile

The ideal candidate should possess:

• A solid background in microengineering, with expertise in plastic fabrication methods for microfluidics.
• Proficiency in CAD design and simulation tools (e.g., COMSOL).
• Experience in cell biology, in vitro culture methods, and bioassays.
• Familiarity with confocal microscopy and related image analysis techniques.

Experience with transwell-based barrier models and fundamental knowledge of microbiological techniques, including bacterial cultures and sterile handling, will be significant advantages. Strong communication skills, a proactive approach to work, and the ability to collaborate across disciplines, alongside fluency in English (both oral and written), are essential qualities.

Workplace

Our group provides access to a state-of-the-art cleanroom and a broad spectrum of engineering and testing equipment, as well as cell culture and biological facilities. Research partners within the AntiResist consortium offer extensive expertise in lung and bladder systems and a wide range of bacterial pathogens, along with specialized cell culture and biosafety facilities. The position is planned for a duration of four years.

We Offer

• Your job with impact: Become part of ETH Zurich, contributing to positive societal change and supported in your professional development.
• Commitment to sustainability and climate neutrality.
• Numerous benefits including public transport season tickets, car sharing, a wide range of sports offered by ASVZ, childcare, and attractive pension benefits.

We Value Diversity

ETH Zurich promotes an inclusive culture that values diversity and ensures equality of opportunity. We nurture a working and learning environment where the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to learn how we foster a fair and supportive atmosphere for growth and success.

Curious? So Are We.

We look forward to receiving your online application, which should include:

• A CV
• A concise motivation statement for the advertised position
• Complete academic transcripts
• Two reference letters

Only applications matching the job profile will be considered. Apply online using the form below.

For further information about the Bio Engineering Laboratory, please visit our website. For specific inquiries regarding the position, feel free to reach out exclusively via email to amanzhol.kurmashev@bsse.ethz.ch.

About ETH Zurich

ETH Zurich is one of the world’s leading universities specializing in science and technology. Renowned for our exceptional education and cutting-edge research, we actively transfer new knowledge to society. With over 30,000 members from more than 120 countries, ETH Zurich fosters independent thought and excellence in an inspiring environment. Located in the heart of Europe, we collaborate globally to develop solutions for today's challenges and those of the future.