PhD Opening in Bioengineering: Microfluidic in-vitro Barrier Models for Bacterial Lung and Bladder Infections (Male/Female)

PhD Opening in Bioengineering: Microfluidic In-vitro Barrier Models for Bacterial Lung and Bladder Infections

100%, Basel, fixed-term

The Bio Engineering Laboratory at the Department of Biosystems of ETH Zurich in Basel is excited to announce a PhD position focusing on the Engineering of Microfluidic In-vitro Barrier Models for Bacterial Lung and Bladder Infections. We are seeking a highly motivated and enthusiastic PhD student to join our international team in Basel, Switzerland.

This role is part of the National Competence Center of Research (NCCR) - Antiresist, which brings together clinicians, academic, and industrial research partners from various disciplines. Currently, we are developing a microfluidic platform aimed at studying bacterial lung and bladder infections, as well as testing new antibacterial drugs. This innovative platform includes a microfluidic system for culturing advanced in-vitro lung and bladder barrier models (membrane-based organ-on-chip models) and for exposing these models to bacteria and potential drug compounds. Across various analysis methods, such as fluorescence microscopy, mass spectrometry, TEER, and permeability assays, we continuously monitor barrier-layer status and viability.

Job Description

The candidate will enhance a microfluidic platform designed for culturing transwell-based lung and bladder organoid models in collaboration with infection biologists from the Biozentrum (University of Basel). Key objectives include:

• Investigating the mechanisms underlying bacterial infections and the rise of antimicrobial resistance.
• Evaluating novel treatment strategies.
• Optimizing the platform for translational applications suitable for clinical and industrial testing.

Profile

For this highly interdisciplinary project, a suitable candidate should possess:

• A solid background in microengineering, including plastic fabrication methods for microfluidics.
• Proficiency in CAD design and simulation tools (e.g., COMSOL).
• Experience in cell biology, in vitro culture methods, and bioassays.
• Familiarity with confocal microscopy and associated image analysis methods.

Experience with transwell-based barrier models and biology is a strong advantage. Basic knowledge of microbiological techniques, including bacterial cultures, sterile handling, and infection assays, is highly appreciated. Strong communication skills, a proactive work ethic, the ability to collaborate across disciplines, and fluency in English (both oral and written) are essential attributes.

Workplace

A state-of-the-art cleanroom, along with an extensive range of engineering and testing equipment, cell-culture, and biological facilities, will be available to the candidate. Our research partners in the AntiResist consortium offer valuable expertise in lung and bladder systems, as well as a broad spectrum of bacterial pathogens. They also provide specialized cell culture and biosafety facilities.

The position is planned for a duration of four years.

We Offer

• An impactful work environment: Become part of ETH Zurich, which not only supports your professional development but also actively contributes to positive societal change.
• A commitment to sustainability and climate neutrality.
• Numerous benefits, such as public transport season tickets, car sharing options, a diverse range of sports offered by ASVZ, childcare, and attractive pension benefits.

We Value Diversity

In line with our values, ETH Zurich fosters an inclusive culture. We promote equality of opportunity, value diversity, and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to learn how we ensure a fair and open environment that allows everyone to grow and flourish.

Curious? So Are We.

We look forward to receiving your online application. Apply online using the form below, including:

• A CV
• A short and specific motivation statement for the advertised position
• Complete academic transcripts
• Two reference letters

Please note that only applications matching the job profile will be considered.

For further information about the Bio Engineering Laboratory, please visit our website. For inquiries regarding the position, feel free to reach out to amanzhol.kurmashev@bsse.ethz.ch exclusively via e-mail.

About ETH Zürich

ETH Zurich is one of the world’s leading universities specializing in science and technology, renowned for excellent education, cutting-edge research, and the direct transfer of new knowledge into society. Over 30,000 individuals from more than 120 countries find ETH Zurich to be a place that fosters independent thinking and inspires excellence. Situated in the heart of Europe and connected globally, we collaborate to address the challenges of today and tomorrow.