PhD Candidate on the Neurocognitive Mechanisms of Repetitive Negative Thoughts / PhD Candidate on the Neurocognitive Mechanisms of Repetitive Negative Thoughts

PhD Position - The Neurocognitive Mechanisms of Repetitive Negative Thoughts

100%, Zurich, fixed-term

A World-Class Research Environment at the Intersection of Neuroscience and Technology

The Neural Control of Movement Lab, led by Prof. Dr. Nicole Wenderoth, and the Brain-Body Regulation Lab, led by Prof. Dr. Sarah Meissner at the Department of Health Sciences and Technology (D-HEST) of ETH Zurich, invite exceptional candidates to explore a PhD position focused on the Neurocognitive Mechanisms of Repetitive Negative Thoughts (RNT). The NCM Lab aims to understand how the brain controls behavior while developing non-invasive interfaces to modulate brain function during wake and sleep. Meanwhile, the BBR Lab investigates the mechanisms underpinning brain arousal and its interactions with other bodily systems.

Together, both labs utilize state-of-the-art neuroimaging and biofeedback techniques, committed to translating fundamental neuroscience insights into impactful applications. D-HEST emphasizes interdisciplinary collaboration, innovation, and real-world application to improve quality of life. Located in the heart of Zurich, Switzerland, the department provides a stimulating environment that bridges world-class basic research and clinical application, with strong connections to leading industry partners.

Project Background

Repetitive negative thoughts (RNT) are persistent, intrusive, and maladaptive thought patterns central to conditions such as depression and anxiety. Despite their clinical significance, the neurocognitive mechanisms underlying RNT are not fully understood.

This project will test the novel hypothesis that RNT arises from reduced sensitivity to environmental change, manifested as impaired adaptation to environmental volatility, driven by abnormal noradrenergic signaling. In close collaboration with the University of Oxford, we plan to combine cutting-edge computational modeling of human behavior with pupillometry and functional magnetic resonance imaging (fMRI) to address this critical question.

Job Description

The successful candidate will design and conduct human experiments that modulate noradrenergic activity using a pupil-based self-regulation approach developed in our lab (Meissner et al., Nature Human Behaviour, 2024), while measuring RNT, behavior, and brain activity using fMRI.

Your responsibilities will include:

• Designing and implementing sophisticated experimental paradigms for human participants
• Acquiring multimodal data, including pupillometry, behavioral measures, and fMRI
• Integrating real-time pupil-based self-regulation into adaptive learning cognitive tasks (using Python/MATLAB)
• Applying computational models of behavior and cognition
• Analyzing high-dimensional datasets (behavioral, physiological, neuroimaging)
• Publishing findings in leading international journals and presenting at top-tier conferences

This interdisciplinary project uniquely combines computational neuroscience, experimental psychology, physiology, and neuroimaging, offering an exceptional opportunity to engage with multiple cutting-edge methodologies. Hands-on experimental work will be a substantial component of the position.

Profile

We seek a candidate with:

• A Master's degree (or near completion) in human neuroscience, neurophysiology, experimental psychology, biomedical engineering, health sciences, or a related field
• Experience and enthusiasm for data collection in human participants
• Strong programming skills (e.g., MATLAB, Python) and an interest in computational approaches
• Experience with analyzing electrophysiological data and/or fMRI data
• A solid understanding of experimental design and statistical analysis
• A proven track record in scientific writing
• A high level of independence, initiative, and problem-solving ability
• Excellent communication skills and a strong commitment to scientific excellence
• Intellectual curiosity and enthusiasm for interdisciplinary research
• Fluency in English; proficiency in German is a plus

Workplace

ETH Zurich is renowned as one of the world’s leading universities in science and technology. We pride ourselves on our outstanding education, groundbreaking research, and direct transfer of knowledge into society. Over 30,000 individuals from more than 120 countries find a home where independent thinking is encouraged, and excellence is fostered. Situated in the heart of Europe and maintaining connections worldwide, we collaborate to develop solutions for global challenges.

Apply Online

Apply online using the form below. Only applications matching the job profile will be considered.

We Value Diversity and Sustainability

ETH Zurich is committed to fostering an inclusive culture. We promote equal opportunities, value diversity, and nurture a working environment where the rights and dignity of all our staff and students are respected. Sustainability is a core value, and we consistently strive toward a climate-neutral future.

Curious? So Are We!

We look forward to receiving your online application, including the following documents:

• Curriculum Vitae detailing your educational history and publications
• A research motivation statement of a maximum of two A4 pages outlining your interests, goals, and relevant experiences
• Diplomas
• Contact information for at least two references, including their professional relationship to you

For more information about the Neural Control of Movement Lab, please visit our website. For inquiries regarding the position, please contact Dr. Weronika Potok-Szybińska at weronika.potok@hest.ethz.ch or Prof. Nicole Wenderoth at nicole.wenderoth@hest.ethz.ch.

Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.