PhD Candidate in Radiopharmaceutical Sciences / PhD Candidate in Radiopharmaceutical Sciences

PhD Position in Radiopharmaceutical Sciences: Glycoengineered Peptides and Nanobodies for Imaging and Therapy

100%, Zurich, fixed-term

The Center for Radiopharmaceutical Sciences (CRS), a joint research center of ETH Zurich and the Paul Scherrer Institute (PSI), is internationally recognized for its pioneering research in radiopharmaceutical chemistry and targeted radionuclide therapy. The research group of Prof. Roger Schibli develops innovative radiopharmaceuticals for the diagnosis and treatment of cancer and other severe diseases.

We are seeking a highly motivated PhD candidate to join the Schibli Group within a newly funded interdisciplinary ETH research project conducted in close collaboration with the laboratory of Prof. Kaspar Locher (Department of Biology, ETH Zurich).

Project Background

Peptides and nanobodies are highly promising molecules for molecular imaging and targeted therapies. However, their clinical translation is often limited by unfavorable pharmacokinetic properties, including rapid blood clearance and high kidney uptake.

This project aims to investigate how defined N-glycosylation can improve the biological and pharmacological properties of therapeutic and diagnostic peptides and nanobodies. Novel glycoengineered biomolecules generated in the Locher laboratory will be radiolabeled and systematically evaluated using advanced in vitro and in vivo methodologies established in the Schibli laboratory. The project combines cutting-edge glycobiology, radiopharmaceutical sciences, targeted radionuclide therapy, and translational research.

Job Description

As a PhD student, you will:

• Develop and optimize radiolabeling strategies for glycosylated peptides and nanobodies using diagnostic and therapeutic radionuclides.
• Perform quality control and analytical characterization of newly developed radiopharmaceuticals.
• Conduct cell-based binding, uptake, and internalization studies.
• Plan, perform, and analyze preclinical biodistribution, PET, and SPECT imaging studies in mouse models.
• Investigate pharmacokinetic and pharmacodynamic properties of novel radiolabeled compounds.
• Work in an interdisciplinary environment.
• Collaborate closely with a PhD student in the Locher laboratory to design and optimize glycosylated peptide and nanobody constructs.
• Present research findings at international conferences and publish results in leading scientific journals.

Profile

You should have:

• A Master's degree with an excellent academic record in Chemistry, Pharmaceutical Sciences, Biochemistry, Molecular Biology, Biotechnology, or a related discipline.
• Strong interest in radiopharmaceutical sciences, molecular imaging, protein engineering, glycobiology, or bioconjugation chemistry.
• Practical experience in one or more of the following areas:
• Radiochemistry or radiopharmacy
• Cell biology and cell culture techniques
• Protein or peptide chemistry
• Preclinical in vivo research
• Excellent organizational and problem-solving skills.
• Ability to work independently as well as collaboratively in an interdisciplinary and international environment.
• Excellent written and oral communication skills in English.

Prior experience in radiopharmaceutical research, PET/SPECT imaging, or animal studies is considered an advantage but is not required.

Workplace

Join our dynamic team at the forefront of radiopharmaceutical research, contributing to innovative diagnostic and therapeutic applications that directly benefit patients.

What We Offer

• An opportunity to work at the forefront of radiopharmaceutical research and development.
• Diverse opportunities for professional and personal development through internal and external training courses, workshops, and conferences.
• Attractive prospects for scientific and professional career growth within an interdisciplinary research environment.
• Support from experienced colleagues, active knowledge sharing, and mentoring within the team.
• An open, respectful, and international working culture that values diverse backgrounds and perspectives.
• Access to state-of-the-art research infrastructure at one of Switzerland's leading research institutions.
• Close collaboration within a motivated team characterized by mutual support and constructive feedback.

We Value Diversity and Sustainability

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity, and nurture a working and learning environment where the rights and dignity of all our staff and students are respected. Sustainability is a core value for us, and we are committed to working towards a climate-neutral future.

Curious? So Are We!

Apply online using the form below. Only applications matching the job profile will be considered.

For further information about the Centre for Radiopharmaceutical Sciences ETH/PSI, please visit our webpage here or here. For scientific inquiries, please contact Dr. Martin Béhé at +41 56 310 28 17 or martin.behe@psi.ch (no applications).

About ETH Zurich

ETH Zurich is one of the world's leading universities specializing in science and technology. Renowned for our excellent education, cutting-edge research, and direct transfer of new knowledge into society, we are home to over 30,000 individuals from more than 120 countries. Together, we strive to develop solutions for the global challenges of today and tomorrow.