PhD Candidate / PhD Candidate (Female)

PhD Opening in Bioengineering: Microfluidic in-vitro Barrier Models for Bacterial Lung and Bladder Infections

100%, Basel, fixed-term

The Bio Engineering Laboratory at the Department of Biosystems of ETH Zurich in Basel is inviting applications for a PhD position in Engineering of Microfluidic in-vitro Barrier Models for Bacterial Lung and Bladder Infections. We are seeking a highly motivated and enthusiastic PhD student who will work in a dynamic international environment in Basel, Switzerland. In the context of the large National Competence Center of Research (NCCR) - Antiresist, we are developing a microfluidic platform to study bacterial lung and bladder infections as well as test new antibacterial drugs. This platform encompasses a microfluidic system that facilitates the culturing of advanced in-vitro lung and bladder barrier models (membrane-based organ-on-chip models) and exposes these models to bacteria and potential drug compounds. We employ a variety of analytical methods, including fluorescence microscopy, mass spectrometry, TEER, and permeability assays, to continuously monitor barrier-layer status and viability.

Job Description

The selected candidate will play a vital role in further developing a microfluidic platform designed for culturing transwell-based lung and bladder organoid models in close collaboration with infection biologists from the Biozentrum (University of Basel). The platform will specifically focus on:

• Studying mechanisms underlying bacterial infections and the emergence of antimicrobial resistance.
• Evaluating novel treatment strategies.

A key objective is to optimize the platform for translational applications that can be used in clinical and industrial settings.

Profile

For this highly interdisciplinary project, a suitable candidate should possess:

• A solid background in microengineering, including plastic fabrication methods for microfluidics.
• Skills in CAD design and simulation tools (e.g., COMSOL).
• Experience in cell biology, in vitro culture methods, and bioassays.
• Experience in confocal microscopy and associated image analysis methods.

Experience with transwell-based barrier models and related biology is a strong advantage. Additionally, basic knowledge of microbiological techniques, including bacterial cultures, sterile handling, and infection assays, is highly appreciated. Strong communication skills, a proactive work attitude, the ability to work collaboratively across disciplines, and fluency in English (oral and written) are important assets.

Workplace

A state-of-the-art cleanroom, a broad spectrum of engineering and testing equipment, as well as cell culture and biological facilities are available within the group. Research partners within the AntiResist consortium contribute extensive expertise in lung and bladder systems, as well as a broad range of bacterial pathogens, and provide specific cell culture and biosafety facilities. The position is planned for 4 years.

We Offer

• Your opportunity to make an impact: Join ETH Zurich, which not only supports your professional development but also actively contributes to positive societal change.
• Commitment to a sustainable and climate-neutral university.
• A range of benefits, including public transport season tickets, car sharing, a variety of sports offered by the ASVZ, childcare services, and attractive pension benefits.

We Value Diversity

In alignment with our values, ETH Zurich promotes an inclusive culture. We are committed to equality of opportunity, value diversity, and nurture a respectful working and learning environment for all staff and students. Visit our Equal Opportunities and Diversity website to understand how we foster a fair and open environment that allows everyone to thrive.

Curious? So Are We.

We look forward to receiving your online application, which should include:

• A CV.
• A short and specific motivation statement for the advertised position.
• Complete academic transcripts.
• Two reference letters.

Please apply online using the form below. Only applications matching the job profile will be considered.

For further information about the Bio Engineering Laboratory, please visit our website. For inquiries related to the position, contact amanzhol.kurmashev@bsse.ethz.ch exclusively via e-mail.

About ETH Zurich

ETH Zurich is a leading university in science and technology, renowned for its excellent education, groundbreaking fundamental research, and direct knowledge transfer to society. Over 30,000 individuals from more than 120 countries find our university to be a place that fosters independent thinking and inspires excellence. Positioned in the heart of Europe, we forge connections around the world to develop solutions for today's and tomorrow's global challenges.