PhD Candidate in Bioengineering / PhD Candidate in Bioengineering

PhD Opening in Bioengineering: Microfluidic In-Vitro Barrier Models for Bacterial Lung and Bladder Infections

100%, Basel, Fixed-Term

The Bio Engineering Laboratory at the Department of Biosystems of ETH Zurich in Basel is inviting applications for a PhD position focused on the Engineering of Microfluidic In-Vitro Barrier Models for Bacterial Lung and Bladder Infections. We are seeking a highly motivated and enthusiastic PhD student who will thrive in our international environment in Basel, Switzerland. This position is part of a large National Competence Center of Research (NCCR) - Antiresist, which involves collaboration among clinicians, academic researchers, and industry partners across multiple disciplines. The objective is to develop a microfluidic platform for studying bacterial lung and bladder infections and testing new antibacterial drugs. This platform includes a microfluidic system for culturing advanced in-vitro lung and bladder barrier models (membrane-based organ-on-chip models) and exposing these models to bacteria and potential drug candidates. A variety of analytical methods (fluorescence microscopy, mass spectrometry, TEER, permeability assays) will be utilized to analyze and monitor barrier-layer status and viability continuously.

Job Description

The candidate will further develop a microfluidic platform designed for culturing transwell-based lung and bladder organoid models in close collaboration with infection biologists from the Biozentrum (University of Basel). The platform will be utilized to:

• Study the mechanisms underlying bacterial infections and the emergence of antimicrobial resistance,
• Evaluate novel treatment strategies.

A key objective is to optimize the platform for translational applications that can be used in clinical and industrial settings.

Profile

For this highly interdisciplinary project, suitable candidates should possess:

• A solid background in microengineering, including plastic fabrication methods for microfluidics,
• Skills in CAD design and simulation tools (e.g., COMSOL),
• Experience in cell biology, *in vitro* culture methods, and bioassays,
• Experience in confocal microscopy and associated image analysis methods.

Experience with transwell-based barrier models and biology is a strong advantage, along with a basic knowledge of microbiological techniques, including bacterial cultures, sterile handling, and infection assays. Strong communication skills, proactive work attitude, and the ability to collaborate across disciplines, as well as fluency in English (both oral and written), are essential assets.

Workplace

A state-of-the-art cleanroom, a broad spectrum of engineering and testing equipment, and cell-culture and biological facilities are available in the group. Research partners within the AntiResist consortium bring extensive expertise in lung and bladder systems and a diverse range of bacterial pathogens. They also provide specific cell culture and biosafety facilities.

The position is planned for 4 years.

We Offer

• Your role will have a significant impact: Become part of ETH Zurich, which supports your professional development and actively contributes to positive change in society,
• We are dedicated to a sustainable and climate-neutral university,
• You can expect numerous benefits, such as public transport season tickets, car sharing, a wide range of sports offered by ASVZ, childcare, and attractive pension benefits.

We Value Diversity

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity, and nurture a working and learning environment where the rights and dignity of all staff and students are respected. Visit our Equal Opportunities and Diversity website to learn how we maintain a fair and open environment that allows everyone to thrive.

Curious? So Are We.

We look forward to receiving your online application, including:

• A CV,
• A short and specific motivation statement for the advertised position,
• Complete academic transcripts,
• Two reference letters.

Please apply online using the form below. Only applications matching the job profile will be considered.

For further information about the Bio Engineering Laboratory, you can visit our website. For more inquiries about the position, please contact us exclusively via email at amanzhol.kurmashev@bsse.ethz.ch.

About ETH Zurich

ETH Zurich is one of the world’s leading universities specializing in science and technology. We are renowned for our excellent education, cutting-edge fundamental research, and direct transfer of new knowledge into society. Over 30,000 individuals from more than 120 countries find ETH Zurich to be a place that fosters independent thinking and inspires excellence. Located in the heart of Europe and forging connections all over the globe, we collaborate to develop solutions for the global challenges of today and tomorrow.