Laboratory Technician in Rapid Organism Detection through Environmental DNA using CRISPR-Cas / Laboratory Technicienne in Rapid Organism Detection through Environmental DNA using CRISPR-Cas

Laboratory Technician in Rapid Organism Detection through Environmental DNA Using CRISPR-Cas

60%-80%, Zurich, fixed-term

The Laboratory of Ecosystems and Landscape Evolution (ELE) and the Genome Engineering and Measurement Lab (GEML) at ETH Zurich are seeking a laboratory technician to join a project focused on developing rapid CRISPR-based environmental DNA (eDNA) detection technologies. The Laboratory of Ecosystem and Landscape Evolution studies the mechanisms shaping biodiversity patterns across spatial and temporal scales and their responses to global changes. GEML serves as a knowledge and technology hub, bridging the scientific community with rapidly evolving genome engineering methods and techniques. This position is part of a collaborative, interdisciplinary effort that blends biodiversity research, molecular biology, and engineering, with a strong emphasis on translating scientific innovation into applied environmental solutions.

Project Background

The systematic monitoring of living organisms, from pathogens and pests to agricultural species and biodiversity, is becoming increasingly essential for long-term societal well-being. A significant challenge in this field is the early, reliable, and efficient detection of disruptive species (e.g., pests or pathogens), enabling timely intervention and informed management decisions. In this project, we are developing a programmable rapid eDNA detection platform based on CRISPR-Cas reactions for swift and cost-effective organism detection across diverse environmental settings.

Job Description

• Join a motivated team in the early stages of a new venture.
• Contribute to the development of a potential spin-off, should the project demonstrate traction and alignment.
• Be responsible for the collection and processing of eDNA samples from various environments, as well as the development, testing, and optimization of molecular reactions and detection methods under laboratory and field conditions.
• Execute and refine molecular biology workflows, troubleshoot experiments independently, and improve robustness and reproducibility.
• Support the generation of high-quality, reproducible data suitable for intellectual property (IP) development, regulatory pathways, and potential commercial use.
• Collaborate closely with the project lead to shape technical direction, set priorities, and iteratively refine the platform.
• Engage with external partners and communicate effectively with various stakeholders as the project matures and demonstrates scientific and commercial viability.

Duration: The position is fixed for 12 months (80%). The project is expected to continue within an ETH spin-off.

Profile

• Master's degree in molecular biology, biochemistry, biomedical engineering, or related fields.
• Hands-on experience with standard molecular laboratory techniques (e.g., DNA/RNA extractions, PCR, qPCR).
• Experience in method development and testing protocols under laboratory conditions.
• Ability to work independently and efficiently plan, document, and execute experiments.
• Strong interest in translating scientific findings into applications, including IP and commercialization.
• Willingness to engage in broader venture-building activities.
• Industrial or product design experience is advantageous.
• Experience with CRISPR-Cas protocols and environmental DNA samples is a plus.
• Ability to integrate concepts from different disciplines efficiently and adapt to evolving project needs.
• Excellent communication and writing skills (English + one official Swiss language).

Workplace

You will collaborate with a group of scientists — including technicians, graduate students, postdocs, and senior scientists — to streamline and optimize experimental procedures in the CRISPR/eDNA research domain. The focus will not only be on basic research but also on applied research fields, offering a variety of projects and opportunities to get involved. You will work in a vibrant international team, gaining the unique opportunity to continuously refine and expand your interpersonal and methodological skills.

• A stimulating academic environment at one of the world's leading technical universities.
• Opportunity to contribute to impactful projects that benefit biodiversity.

We Value Diversity and Sustainability

ETH Zurich promotes an inclusive culture that encourages equality of opportunity, values diversity, and nurtures a respectful work and learning environment for all staff and students. We are committed to sustainability and continually working towards a climate-neutral future.

Curious? So Are We.

If you are interested in this opportunity, please apply online using the form below. Only applications matching the job profile will be considered.

For further information about the Laboratory of Ecosystem and Landscape Evolution, please visit our website. Questions regarding the position should be directed to Prof. Loïc Pellissier at loic.pellissier@usys.ethz.ch.

About ETH Zurich

ETH Zurich is one of the world's leading universities specializing in science and technology, renowned for its excellent education and cutting-edge fundamental research. Over 30,000 people from more than 120 countries foster an environment that inspires excellence and promotes independent thinking. Located in the heart of Europe while forging connections globally, we work together to tackle today's and tomorrow's challenges.