ROLE OVERVIEW
We are seeking a motivated and hands-on Investigator to join our Antibody Discovery & Engineering (ADE) department. The successful candidate will play a pivotal role in the early phases of therapeutic antibody discovery, focusing on the generation, screening, and selection of multi-specific antibody candidates. This laboratory-based position involves crucial tasks such as molecular biology, DNA construct generation, antibody expression, purification, and characterization, including developability assessments. While prior experience in antibody discovery and optimization is advantageous, comprehensive training will be provided. You will thrive in a collaborative and dynamic environment, contributing to pipeline programs and the advancement of next-generation biologics.
RESPONSIBILITIES
- Design and generate multi-specific antibody constructs for expression and screening.
- Utilize molecular biology techniques, including microbiology, recombinational cloning, PCR, and DNA sequence analysis.
- Perform antibody and antigen expression in transient systems (e.g., HEK, CHO), including various cell culture activities.
- Support protein purification workflows and buffer exchange (e.g., Protein A, SEC, IMAC).
- Conduct multi-specific antibody developability assays, such as AC-SINS, polyspecificity ELISAs, melting temperature assessments, and purity checks via capillary gel electrophoresis and size exclusion chromatography.
- Engage in basic data analysis while maintaining detailed experimental records in the Lab-book system.
- Contribute to internal reports, data presentations, and method documentation.
- Collaborate with cross-functional teams, including Lead Identification, Protein Sciences, and Cell Sciences.
- Participate in internal meetings and effectively communicate research progress to stakeholders.
- Comply with laboratory safety standards and foster a culture of scientific rigor and teamwork.
EDUCATION AND DESIRED EXPERIENCE
Essential:
- MSc or BSc in Molecular Biology, Biotechnology, Biochemistry, or a related field, with relevant practical experience.
- Strong practical knowledge in molecular biology, particularly DNA manipulation and cloning.
- Excellent communication and collaboration skills.
- Strong scientific curiosity and critical thinking abilities.
- Capability to independently plan, execute, and analyze experiments.
- Organized, flexible, and able to thrive in a dynamic research environment.
- Professional fluency in English, both written and verbal.
Nice to Have (Training Will Be Provided):
- Experience in cell culture (e.g., HEK293, CHO cells).
- Knowledge of protein production and purification methods.
- Exposure to binding kinetics and affinity assessments (e.g., SPR, Octet, CBA).
- Familiarity with antibody sequence analysis, developability profiling, or hit-to-lead workflows.
LOCATION
Join us in a thriving biotech community at Biopôle (https://www.biopole.ch/), overlooking the beautiful shores of Lake Geneva in Lausanne, Switzerland. This position offers a unique opportunity to grow in antibody discovery, work with cutting-edge technologies, and contribute to the development of innovative biologics within a collaborative, fast-paced environment.
Apply online using the form below. Only applications matching the job profile will be considered.