ROLE OVERVIEW
We are seeking a motivated and hands-on Investigator to join our Antibody Discovery & Engineering (ADE) department. The successful candidate will play a vital role in the early phases of therapeutic antibody discovery, concentrating on the generation, screening, and selection of multi-specific antibody candidates.
This laboratory-based position involves molecular biology, DNA construct generation, antibody expression, purification, and characterization, including developability assessments. While prior experience in antibody discovery and optimization is advantageous, training will be provided. You will thrive in a collaborative and dynamic environment, contributing to pipeline programs and advancing next-generation biologics.
RESPONSIBILITIES
- Design and generate multi-specific antibody constructs for expression and screening.
- Apply molecular biology techniques such as microbiology, recombinational cloning, PCR, and DNA sequence analysis.
- Perform expression of antibodies and antigens in transient systems (e.g., HEK, CHO), including cell culture activities.
- Support protein purification workflows and buffer exchange (e.g., Protein A, SEC, IMAC).
- Conduct multi-specific antibody developability assays such as AC-SINS, polyspecificity ELISAs, melting temperature assessment, purity by capillary gel electrophoresis, and size exclusion chromatography.
- Perform basic data analysis and maintain detailed experimental records in the Lab-book system.
- Contribute to internal reports, data presentations, and method documentation.
- Collaborate with cross-functional teams including Lead Identification, Protein Sciences, and Cell Sciences.
- Participate in internal meetings and communicate research progress to stakeholders.
- Comply with laboratory safety standards and foster a culture of scientific rigor and teamwork.
EDUCATION AND DESIRED EXPERIENCE
Essential:
- MSc or BSc in Molecular Biology, Biotechnology, Biochemistry, or a related field with relevant practical experience.
- Strong practical knowledge in molecular biology, including DNA manipulation and cloning.
- Excellent communication and collaboration skills.
- Strong scientific curiosity and critical thinking.
- Ability to plan, execute, and analyze experiments independently.
- Organized, flexible, and capable of thriving in a dynamic research environment.
- Professional fluency in English, both written and verbal.
Nice to Have (Training Will Be Provided):
- Experience in cell culture (e.g., HEK293, CHO cells).
- Knowledge of protein production and purification methods.
- Exposure to binding kinetics and affinity assessment (e.g., SPR, Octet, CBA).
- Familiarity with antibody sequence analysis, developability profiling, or hit-to-lead workflows.
LOCATION
You will join us in a thriving biotech community at Biopôle (https://www.biopole.ch/), overlooking the beautiful shores of Lake Geneva in Lausanne, Switzerland. This position offers a unique opportunity to grow in antibody discovery, work with cutting-edge technologies, and contribute to the development of innovative biologics in a collaborative, fast-paced environment.
Apply online using the form below. Please note that only applications matching the job profile will be considered.