Founding Scientist / Founding Scientistess

Founding Scientist - Antibody/Nanobody Drug Discovery

100%, Basel, fixed-term

The group of Prof. Andreas Moor (D-BSSE, ETH Zurich, located in Basel) is seeking an exceptional, entrepreneurially minded scientist to drive a colorectal-cancer metastasis-prevention antibody/nanobody program from discovery toward the clinic (start immediately or by arrangement).

Your Path: From Fellowship to Founding

Over the next 12 months, you will lead the antibody program toward investor-grade data and strengthen the intellectual property (IP) estate, working hands-on within our translational network. The intended trajectory for the right candidate is to evolve into a founding and scientific leadership role as the venture takes shape.

Project Background

You will operate at the intersection of fundamental research and translational development, advancing nanobody/antibody binders against a validated, disease-relevant target in colorectal-cancer metastasis, building on the lab's own published discoveries. Key responsibilities include:

• Discovery and rigorous screening of novel protein binders.
• Detailed characterization and analysis in an environment that integrates translation, IP, and venture formation as part of the scientific discipline.

We welcome candidates with an MSc or PhD in biotechnology, molecular biology, protein science, or a related field, eager to apply their expertise to high-impact challenges. Prior experience with protein engineering, display technologies (phage, yeast, or ribosome display), or cell-based assays is advantageous.

Job Description

• Experimentation: Design and execute studies to develop and characterize novel antibodies and nanobodies.
• Optimization: Apply molecular biology and protein engineering to enhance binders for affinity, specificity, and stability.
• Assay Development: Create and validate cell-based/organoid assays to assess therapeutic potential and define the therapeutic window.
• Translational Ownership: Contribute hands-on to technology transfer, intellectual property (invention disclosures, FTO literature review), and the evolution of the therapeutic pipeline, including preparing materials for and participating in tech-transfer, partner, and investor discussions.
• Team Management: Supervise and mentor a research technician, taking responsibility for a small team's output.

Profile

• MSc or PhD in a relevant field with a proven hands-on track record in the relevant workflows.
• Technical strength in protein engineering, purification, display assays (phage, yeast, or ribosome), ELISA and BLI, flow cytometry, cell sorting, fluorescence microscopy, and mammalian cell culture.
• Creativity and innovative thinking; ability to operate under pressure and deliver on timelines and budgets.
• Experience with regulatory/drug development and animal experimentation is a plus.

This role is tailored for scientists who:

• Are passionate about antibody/nanobody therapeutics and desire to see their research evolve into tangible clinical solutions.
• Are energized by ownership and driven to advance a project amidst real-world uncertainty.
• Value a collaborative environment where scientific inquiry meets strategic development (IP, spinoffs, and commercialization) and seek hands-on exposure to this process.

Workplace

At ETH Zurich, we foster a culture of diversity and sustainability. We encourage an inclusive environment that promotes opportunities for all, respecting the rights and dignity of our staff and students. Visit our Equal Opportunities and Diversity website to learn more about how we create a fair and open workplace. Sustainability is a core value for us, and we are committed to achieving a climate-neutral future.

Curious? So Are We.

Apply online using the form below. Only applications matching the job profile will be considered.

About ETH Zurich

ETH Zurich is one of the world's leading universities specializing in science and technology. We are renowned for our excellent education, cutting-edge research, and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university a place that promotes independent thinking and inspires excellence. Located in the heart of Europe yet connecting globally, we collaborate to develop solutions for the challenges of today and tomorrow.