Job ID
REQ-10050376
July 01, 2025
Switzerland
Summary
Location: Basel, Switzerland
Full time, onsite, #LI-Onsite
The Biologics Research Center (BRC) at Biomedical Research is seeking a highly skilled Structural Bioinformatician / Computational Chemist specializing in protein structure predictions, protein-protein and ligand interactions, molecular dynamics simulations, and protein/DNA/RNA structure analysis. The ideal candidate will join our Bioinformatics and Biotherapeutics Modelling team and contribute to our innovative biologics projects.
About the Role
Your responsibilities will include:
- Actively contributing to the biologics discovery pipeline and innovation-related programs by applying structural modeling methods to design novel molecules, optimize lead candidates, and develop reagents at different stages of the drug discovery process.
- Assisting scientists across the organization in the analysis and design of biologics sequences and structures, including xRNA therapeutics, while advancing projects from early discovery to optimization stages.
- Applying, developing, and improving computational structural modeling methods to analyze data and design the functional properties of drug candidates.
- Collecting, analyzing, and integrating diverse types of data, including structural data from various projects to build predictive models, formulate hypotheses, and generate actionable insights.
- Contributing to the design, utilization, and enhancement of bioinformatics tools in the molecular modeling field to analyze sequence and structure data for knowledge generation.
- Working closely with experimental scientists, fostering a collaborative and multidisciplinary environment to drive project success.
What You Will Bring to the Role
The ideal candidate should possess the following qualifications and skills:
- Educational Background: Recent Ph.D. (graduated within the last 3-6 months), MS (with 4+ years of relevant industry research experience), or an equivalent degree in theoretical/computational chemistry, bioinformatics, structural biology, or a related field.
- Experience: Prior experience in the pharmaceutical or biotechnology industry is advantageous but not essential. Research or academic experience with a focus on biologics, including RNA or antibody-based therapeutics, is also valuable.
- Technical Expertise: Proficiency in computational structural biology, molecular modeling, molecular dynamics simulations, and structural bioinformatics tools and software (e.g., MOE, Schrodinger, Rosetta, or similar) for structural analysis and structure-based biologics design.
- A comprehensive understanding of RNA structural biology and RNA-ligand interactions is preferred.
- AI/ML Proficiency: Experience in incorporating AI/ML models into in silico workflows, with skills in monitoring performance, retraining, and updating models, is advantageous.
- Analytical Skills: Strong ability to analyze and interpret complex biological data, particularly in the context of protein sequences and structures.
- Programming Skills: Competence in programming languages such as Python, R, or similar, and experience with bioinformatics databases and tools. Familiarity with version control systems like Git for collaborative coding and project management is a plus.
- Innovation: A creative and innovative mindset, with a keen interest in advancing the field of biologics through cutting-edge computational methods.
- Problem-Solving: Demonstrated ability to develop hypotheses, design experiments, and drive projects to successful completion.
- Collaborative Spirit: Excellent communication and teamwork skills, with the ability to work effectively in a multidisciplinary environment.
Important Notes
Only applications matching the job profile will be considered. Apply online using the form below.
Accessibility and Accommodation
Novartis is committed to working with and providing reasonable accommodations to all individuals. If you require assistance during the recruitment process due to a medical condition or disability, please send an e-mail to inclusion.switzerland@novartis.com, including the job requisition number in your message.
Why Novartis
Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate individuals. Collaborating and inspiring each other to achieve breakthroughs that change patients' lives. Are you ready to create a brighter future together?
Learn more about our community.
Join Our Novartis Network
Not the right Novartis role for you? Sign up for our talent community to stay connected and learn about suitable career opportunities as they arise: Talent Network.
Benefits and Rewards
Read our handbook to learn about all the ways we help you thrive personally and professionally: Benefits and Rewards.
Division
Biomedical Research
Business Unit
Pharma Research
Location
Switzerland
Site
Basel (City)
Company / Legal Entity
C028 (FCRS = CH028) Novartis Pharma AG
Functional Area
Data and Digital
Job Type
Full time
Employment Type
Regular
Shift Work
No
Novartis is committed to building an outstanding, inclusive work environment with diverse teams representative of the patients and communities we serve.