Job ID: REQ-10050376
Date: May 20, 2025
Location: Basel, Switzerland
Employment Type: Full time, onsite
Summary
The Biologics Research Center (BRC) at Biomedical Research is seeking a highly skilled Structural Bioinformatician/Computational Chemist specializing in protein structure predictions, protein-protein/ligand interactions, molecular dynamics simulations, and protein/DNA/RNA structure analysis. The ideal candidate will join our Bioinformatics and Biotherapeutics Modeling team to contribute to our innovative biologics projects.
About the Role
Your responsibilities will include:
- Actively contributing to the biologics discovery pipeline and innovation-related programs by applying structure modeling methods to design novel molecules, optimize lead candidates, and develop reagents at various stages of the drug discovery process.
- Assisting scientists across the organization in the analysis and design of biologics sequences and structures, including xRNA therapeutics, advancing projects from early discovery to optimization stages.
- Applying, developing, and improving computational structural modeling methods to analyze data and design functional properties of drug candidates.
- Collecting, analyzing, and integrating diverse types of data, including structural data from various projects, to build predictive models, formulate hypotheses, and generate actionable insights.
- Contributing to the design, utilization, and enhancement of bioinformatics tools in the field of molecular modeling to analyze sequence and structure data for knowledge generation.
- Working closely with experimental scientists to foster a collaborative and multidisciplinary environment to drive project success.
What You Will Bring to the Role
To be successful in this role, the ideal candidate should possess the following qualifications and skills:
- Educational Background: Recent Ph.D. (graduated within the last 3-6 months), MS (with 4+ years of relevant industry research experience), or equivalent degree in theoretical/computational chemistry, bioinformatics, structural biology, or a related field.
- Experience: Prior experience in the pharmaceutical or biotechnology industry is advantageous but not essential. Experience in a research or academic setting with a focus on biologics, including RNA or antibody-based therapeutics, is valuable.
- Technical Expertise: Proficiency in computational structural biology, molecular modeling, molecular dynamics simulations, and structural bioinformatics tools and software (such as MOE, Schrodinger, Rosetta, or similar) for structural analysis and structure-based biologics design.
- AI/ML Proficiency: Experience in incorporating AI/ML models into in silico workflows, monitoring performance, retraining, and updating models is advantageous.
- Analytical Skills: Strong ability to analyze and interpret complex biological data, particularly regarding protein sequences and structures.
- Programming Skills: Competence in programming languages such as Python, R, or similar, and experience with bioinformatics databases and tools. Familiarity with version control systems like Git for collaborative coding and project management is a plus.
- Innovation: A creative and innovative mindset, with a keen interest in advancing the field of biologics through cutting-edge computational methods.
- Problem-Solving: Demonstrated ability to develop hypotheses, design experiments, and drive projects to successful completion.
- Collaborative Spirit: Excellent communication and teamwork skills, with the ability to work effectively in a multidisciplinary environment.
Accessibility and Accommodation
Novartis is committed to working with and providing reasonable accommodation to all individuals. If you need reasonable accommodation for any part of the recruitment process or would like more detailed information about the essential functions of a position, please send an email to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Why Novartis
Helping people with diseases and their families takes more than innovative science. It takes a community of smart, passionate people like you, collaborating, supporting, and inspiring one another. Together, we aim to achieve breakthroughs that change patients' lives. Ready to create a brighter future together? Learn more here.
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Application Process
Apply online using the form below. Only applications matching the job profile will be considered.
Company Overview
Division: Biomedical Research
Business Unit: Pharma Research
Location: Switzerland
Site: Basel (City)
Company / Legal Entity: C028 Novartis Pharma AG
Functional Area: Data and Digital
Job Type: Full time
Shift Work: No
Novartis is committed to building an outstanding, inclusive work environment and diverse teams that reflect the patients and communities we serve.