Expert II - Biologics Structural Bioinformatician / Computational Chemist (80-100%)
Novartis Pharma AG - June 20, 2025
Job ID
REQ-10050376
May 20, 2025
Switzerland
Summary
Location: Basel, Switzerland
Full time, onsite, #LI-Onsite
The Biologics Research Center (BRC) at Biomedical Research is seeking a highly skilled Structural Bioinformatician / Computational Chemist who specializes in protein structure predictions, protein-protein and ligand interactions, molecular dynamics simulations, and protein, DNA, and RNA structure analysis. The ideal candidate will become part of our Bioinformatics and Biotherapeutics Modelling team and contribute to our innovative biologics projects.
About the Role
Your responsibilities will include:
Actively contributing to the biologics discovery pipeline and innovation-related programs by applying structural modeling methods to design novel molecules, optimize lead candidates, and design reagents at various stages of the drug discovery process.
Assisting scientists across the organization in the analysis and design of biologics sequences and structures, including xRNA therapeutics, advancing projects from early discovery to optimization stages.
Applying, developing, and improving computational structural modeling methods to analyze data and design functional properties of drug candidates.
Collecting, analyzing, and integrating diverse types of data, including structural data from different projects, to build predictive models, formulate hypotheses, and generate actionable knowledge.
Contributing to the design, utilization, and improvement of bioinformatics tools in the field of molecular modeling to analyze sequence and structure data for knowledge generation.
Collaborating closely with experimental scientists to foster a multidisciplinary environment and drive project success.
What You Will Bring to the Role
To be successful in this role, the ideal candidate should possess the following qualifications and skills:
Educational Background: Recent Ph.D. (graduated within the last 3-6 months), MS (with 4+ years of relevant industry research experience) or equivalent in theoretical/computational chemistry, bioinformatics, structural biology, or a related field.
Experience: Prior experience in the pharmaceutical or biotechnology industry is advantageous but not essential. Experience in a research or academic setting with a focus on biologics, including RNA or antibody-based therapeutics, is also valuable.
Technical Expertise: Proficiency in computational structural biology, molecular modeling, molecular dynamics simulations, and structural bioinformatics tools and software (MOE, Schrodinger, Rosetta, or similar) for structural analysis and structure-based biologics design.
A comprehensive understanding of RNA structural biology and RNA-ligand interactions is preferred.
AI/ML Proficiency: Experience in incorporating AI/ML models into in silico workflows, as well as monitoring performance, retraining, and updating models, is advantageous.
Analytical Skills: Strong ability to analyze and interpret complex biological data, particularly in the context of protein sequences and structures.
Programming Skills: Competence in programming languages such as Python, R, or similar, and experience with bioinformatics databases and tools. Familiarity with version control systems like Git for collaborative coding and project management is a plus.
Innovation: A creative and innovative mindset, with a keen interest in advancing the field of biologics through cutting-edge computational methods.
Problem-Solving: Demonstrated ability to develop hypotheses, design experiments, and drive projects to successful completion.
Collaborative Spirit: Excellent communication and teamwork skills, with the ability to work effectively in a multidisciplinary environment.
Apply online using the form below. Only applications matching the job profile will be considered.
Accessibility and Accommodation
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Company Details
Division: Biomedical Research Business Unit: Pharma Research Location: Switzerland Site: Basel (City) Company / Legal Entity: C028 (FCRS = CH028) Novartis Pharma AG Functional Area: Data and Digital Job Type: Full time Employment Type: Regular Shift Work: No
Novartis is dedicated to building an outstanding, inclusive work environment with diverse teams representative of the patients and communities we serve.