Doctoral Student / Doctoral Student

Doctoral Student Position - Evaluating Novel Mineral Sources for Treatment of Micronutrient Deficiencies in Humans

100%, Zurich, fixed-term

The ETH Zurich Laboratory of Epigenetics, Nutrition and Metabolism and Sustainable Food Processing Group in the Department of Health Science and Technology are launching a strategic research initiative focused on Microalgae and Plant-Based Foods in Human Nutrition and Health. The Sustainable Food Processing Group emphasizes a system-oriented approach to food production, considering the entire value chain, including societal needs and their environmental, economic, and social impacts. Innovative raw materials are utilized within urban farming and processing concepts to create new pathways for sustainable food supply.

The Laboratory of Epigenetics, Nutrition and Metabolism seeks to uncover the complex interactions between nutrition, metabolism, and the epigenome using advanced techniques such as single-cell and next-generation sequencing, alongside human and murine in vivo and in vitro studies, combined with genome-wide computational and bioinformatic analysis. We are looking to recruit a talented and motivated doctoral student to explore novel mineral sources for treating micronutrient deficiencies in humans, focusing on the absorption and bioavailability of these minerals in vivo through clinical trials.

Project Background

Micronutrient deficiency is a prevalent global health issue, largely stemming from insufficient dietary intake. It is estimated that over 5 billion people lack adequate intake of at least one micronutrient. Mineral deficiencies, particularly of iron, calcium, zinc, and magnesium, are especially prevalent in low- and middle-income countries where low-mineral diets primarily affect women and children.

Dietary minerals are typically sourced from various foods, including animal-based products such as meat, dairy, and seafood, as well as plant-based foods like legumes, cereals, nuts, seeds, and leafy vegetables. However, reliance on conventional animal-based foods raises issues of environmental sustainability, ethical considerations, and dietary preferences. Although plant-based foods are more sustainable, they often contain lower levels of minerals and are less bioaccessible and bioavailable due to absorption inhibitors such as phytates and polyphenols. Therefore, it is crucial to explore alternative, more sustainable, and mineral-rich food sources that can effectively address these global deficiencies.

Novel mineral sources—such as microalgae—hold great potential as rich sources of essential minerals including iron, calcium, zinc, and magnesium, alongside proteins, lipids, vitamins, and other bioactive compounds. Yet, their bioavailability needs to be thoroughly assessed through in vivo clinical trials before wide-scale application in humans.

Job Description

As a doctoral student, you will be responsible for conducting research focused on the absorption and bioavailability of novel mineral sources through clinical trials. Your main tasks will include:

• Summarizing existing knowledge on minerals from novel sources for human nutrition and health
• Designing intervention meals (including sensory tests) for clinical trials
• Assessing the bioaccessibility of minerals in vitro
• Evaluating mineral bioavailability in vitro
• Conducting clinical trials related to human nutrition enriched with novel mineral sources (key responsibility)
• Supporting teaching activities and co-supervising MSc and BSc students
• Acting at the interface between science and technology while collaborating with partners from academia and industry
• Assisting in grant applications and related activities with various ETH research centers

Profile

• A Master’s degree in Nutrition and Health, Clinical Trials, Food Science and Technology (with significant nutrition or clinical experience), or relevant fields
• A strong passion for nutrition and health, sustainability, and innovative food sources
• Expertise and interest in human/clinical research (GCP certificate required, but can be obtained after starting)
• Experience and keen interest in nutrition assessment using in vivo models
• Ability to thrive in a dynamic, international, and interdisciplinary team
• Strong collaboration skills with diverse teams and national/international partners
• Ability to work independently and supervise students
• Exceptional verbal and written communication skills in English
• Scientific curiosity and motivation for rigorous experimental work

Workplace

You will be part of a leading research team focused on Microalgae and Plant-Based Foods in Human Nutrition and Health, receiving strong support from both ETH groups. Our state-of-the-art research facilities provide an excellent and collaborative working environment. ETH Zurich offers outstanding training opportunities for career development, alongside strong networks in sustainable food and nutrition. You will also receive support from research assistants as needed, and living expenses will be underpinned by a fixed-rate doctoral student salary in accordance with ETH guidelines.

We Value Diversity and Sustainability

ETH Zurich fosters an inclusive culture. We advocate for equality of opportunity, value diversity, and maintain a supportive working and learning environment where the rights and dignity of all staff and students are upheld. Sustainability is a core value; we continually strive towards a climate-neutral future.

Curious? So Are We!

Apply online using the form below. Only applications matching the job profile will be considered.

About ETH Zurich

ETH Zurich is among the world's leading universities specializing in science and technology. We are recognized for our excellent education, groundbreaking fundamental research, and the direct application of new knowledge to society. Over 30,000 individuals from more than 120 countries find our university a place that promotes independent thinking and nurtures excellence. Positioned in the heart of Europe, yet connecting globally, we collaborate to devise solutions to today's and tomorrow's global challenges.