Director Non-Clinical PK/PD / Directress Non-Clinical PK/PD

Job Opportunity: Scientist - PK/PD Activities

Bright Peak Therapeutics is seeking an experienced and highly motivated scientist to spearhead our PK/PD activities within the NCD team. This role presents a unique opportunity to make an immediate impact on the development of Bright Peak’s expanding pipeline of novel multi-specific immunoconjugates. By contributing your expertise and scientific skills, you will play a crucial role in both project teams and broader strategic discussions. As a small company, this position involves both leadership and hands-on experimental design and execution, in close collaboration with our network of consultants and CRO partners.

The ideal candidate will possess a strong background in biologics NCD, particularly with complex multi-specific formats. Leveraging your profound knowledge in this area, you will help lead our mission to develop groundbreaking multi-functional therapeutics. We value a broad perspective and enthusiasm for exploring new therapeutic areas, with a proven success record in the development of immuno-oncology projects being essential.

Location

This position is based in Allschwil, on the outskirts of Basel. While there is flexibility for remote work, we are looking for a predominantly on-site presence.

Responsibilities

• Design and implement integrated non-clinical PK/PD strategies from research and discovery through early clinical development.
• Collaborate with cross-functional teams to align non-clinical DMPK activities with overall program objectives.
• Design and execute PK/PD studies to enable first-in-human trials, ensuring high-quality and scientifically sound conduct.
• Manage, analyze, review, summarize, interpret, report, and communicate results from PK/PD studies.
• Develop and implement PK/PD optimization strategies, including ensuring appropriate exposure in preclinical species for safety testing.
• Oversee the authoring and reviewing of non-clinical sections of regulatory documents and reports.
• Ensure compliance with regulatory requirements and represent the non-clinical development function in health authority interactions.
• Select, manage, and monitor external CROs and consultants.
• Stay current with the latest developments in the field.

Qualifications

• PhD in Pharmaceutical or Life Sciences with 5–10 years of relevant experience in non-clinical development within the biotechnology or pharmaceutical industry.
• Proven track record of advancing biotherapeutic candidates from early research through non-clinical development, IND submission, and beyond.
• Strong experience in the non-clinical development of therapeutic proteins, encompassing broad expertise in PK/PD, pharmacology, and safety principles of biotherapeutics.
• Familiarity with GLP regulations and regulatory requirements for non-clinical development, including experience in regulatory submissions.
• Relevant expertise in immuno-oncology, with additional experience in cardiometabolic diseases considered a plus.
• Demonstrated ability to design, interpret, and report on PK/PD studies.
• Proven experience working with CROs, academic partners, and external expert consultants.

Personal Skills

• Highly motivated with a proactive attitude, and a passion for working in a dynamic, fast-paced, and entrepreneurial environment.
• Excellence in building and maintaining effective working relationships with key internal and external stakeholders.
• Exceptional leadership, communication, and interpersonal skills.
• Strong planning abilities with a track record of delivering outputs on agreed timelines.
• Able to work both independently and as part of a team.

About Bright Peak Therapeutics

Bright Peak Therapeutics is a pioneering biotech company based in Basel and San Diego, utilizing a combination of chemical synthesis, protein engineering, and recombinant technology to create and develop immunotherapies for cancer and other therapeutic areas. We produce and chemically conjugate enhanced cytokine payloads to existing antibodies to generate Bright Peak Immunoconjugates. The company was spun out from the ETH Zürich in 2017 and is currently conducting Phase 1 clinical trials for a PD1-IL18 immunoconjugate (BPT567).

In addition to a competitive salary and equity options, we offer a comfortable working environment, modern and well-equipped offices and labs, as well as beverages and snacks. We organize regular social events and provide free parking options if needed. We prioritize a supportive, enjoyable, and inclusive work culture. Diversity and equality of opportunity are important to us, and we encourage applications from individuals of all social and cultural backgrounds.

Apply online using the form below. Please note that only applications matching the job profile will be considered.